| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Upregulation of Connexin 30 in Intestinal Phenotype Gastric Cancer and Its Reduction during Tumor Progression |
|
言語 |
en |
| 作成者 |
Sentani, Kazuhiro
Oue, Naohide
Sakamoto, Naoya
Anami, Katsuhiro
Naito, Yutaka
Aoyagi, Kazuhiko
Sasaki, Hiroki
Yasui, Wataru
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2010 S. Karger AG, Basel |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Gastric cancer |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Intestinal phenotype |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Connexin 30 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Microarray |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Aims: The mucin phenotype is associated with clinicopathological findings and tumorigenesis in gastric cancer (GC). The aim was to search for a novel marker regulating the intestinal phenotype of GC. Methods and Results: We performed microarray analyses, and GJB6 (encoding connexin 30) was identified as a gene associated with the intestinal phenotype. Immunostaining of connexin 30 in 169 GC cases revealed that 47 (28%) cases were positive for connexin 30, while connexin 30 was negative in nonneoplastic gastric tissue. Connexin 30-negative GC cases showed more advanced T grade, N grade, and tumor stage than connexin 30-positive GC cases. Six (13%) GC cases positive for connexin 30 were histologically of the differentiated type. In addition, the expression of gastric and intestinal phenotypes of GC was examined by immunostaining for MUC5AC, MUC6, MUC2, and CD10. Connexin 30 expression occurred more frequently in the intestinal phenotype (48%) than in other phenotypes (21%) of GC. Conclusion: These results indicate that the expression of connexin 30 is a novel differentiation marker mediating the biological behavior of intestinal phenotype GC. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Karger |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1159/000314966 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1159/000314966 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1015-2008 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1077272X |
| 開始ページ |
|
|
開始ページ |
241 |
| 書誌情報 |
Pathobiology
Pathobiology
巻 77,
号 5,
p. 241-248,
発行日 2010
|
| 旧ID |
30863 |
Pathobiology_77_241.pdf (414.4 KB)
