| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice |
|
言語 |
en |
| 作成者 |
Morita, Katsuya
Morioka, Norimitsu
Abdin, Joynal
Kitayama, Shigeo
Nakata, Yoshihiro
Dohi, Toshihiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2004 Elsevier B.V |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
RAF |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Tactile allodynia |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Thermal hyperalgesia |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Capsaicin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
ATP |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Platelet-activating factor (PAF) is a potent inflammatory lipid mediator in peripheral tissues. However, its role in mediation of nociception in central nervous system is unknown. In the present study, whether PAF plays some role in pain transduction in the spinal cord was studied in mice. Intrathecal injection of PAF induced tactile pain, tactile allodynia at as low as 10 fg ~ 1 pg with a peak response at 100 fg, while lyso-PAF was without effect in the range of doses. Tactile allodynia induced by PAF was blocked by a PAF receptor antagonists, TCV-309, WEB 2086 and BN 50739. The expression of PAF receptor mRNA by RT-PCR was observed in DRG and spinal cord in mice. ATP P2X receptor antagonists, pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (PPADS) and 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5-triphosphate (TNP-ATP), NMDA receptor antagonist, MK 801 and nitric oxide synthetase inhibitor, 7-nitroindazole blocked the PAF-induced tactile allodynia. PAF-induced tactile allodynia and thermal hyperalgesia disappeared in neonatally capsaicin-treated adult mice, while tactile allodynia but not thermal hyperalgesia induced by intrathecally injected α,β-methylene ATP, a P2X receptor agonist, was capsaicin-insensitive. The present study demonstrated that PAF is a potent inducer of tactile allodynia and thermal hyperalgesia at the level of the spinal cord. PAF-evoked tactile allodynia is suggested to be mediated by ATP and the following NMDA and NO cascade through capsaicin-sensitive fiber, different from exogenously injected α,β-methylene ATP which is insensitive to capsaicin treatment. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier B.V |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.pain.2004.07.016 |
| 関連情報 |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
15363879 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.pain.2004.07.016 |
| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0304-3959 |
| 開始ページ |
|
|
開始ページ |
351 |
| 書誌情報 |
Pain
Pain
巻 111,
号 3,
p. 351-359,
発行日 2004-10
|
| 旧ID |
111 |
Pain_111-3_351-359_2004-10.pdf (282.1 KB)
