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Risk Score to Predict 1-Year Mortality after Haemodialysis Initiation in Patients with Stage 5 Chronic Kidney Disease under Predialysis Nephrology Care

https://hiroshima.repo.nii.ac.jp/records/2007959
https://hiroshima.repo.nii.ac.jp/records/2007959
7cc0bf2b-9e0f-4150-a71e-54e8e1745514
名前 / ファイル ライセンス アクション
PLoSONE_10_e0129180.pdf PLoSONE_10_e0129180.pdf (388.3 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Risk Score to Predict 1-Year Mortality after Haemodialysis Initiation in Patients with Stage 5 Chronic Kidney Disease under Predialysis Nephrology Care
言語 en
作成者 Doi, Toshiki

× Doi, Toshiki

en Doi, Toshiki

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Yamamoto, Suguru

× Yamamoto, Suguru

en Yamamoto, Suguru

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Morinaga, Takatoshi

× Morinaga, Takatoshi

en Morinaga, Takatoshi

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Sada, Ken-ei

× Sada, Ken-ei

en Sada, Ken-ei

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Kurita, Noriaki

× Kurita, Noriaki

en Kurita, Noriaki

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Onishi, Yoshihiro

× Onishi, Yoshihiro

en Onishi, Yoshihiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © 2015 Doi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
内容記述
内容記述 Background Few risk scores are available for predicting mortality in chronic kidney disease (CKD) patients undergoing predialysis nephrology care. Here, we developed a risk score using predialysis nephrology practice data to predict 1-year mortality following the initiation of haemodialysis (HD) for CKD patients. Methods This was a multicenter cohort study involving CKD patients who started HD between April 2006 and March 2011 at 21 institutions with nephrology care services. Patients who had not received predialysis nephrology care at an estimated glomerular filtration rate (eGFR) of approximately 10 mL/min per 1.73 m2 were excluded. Twenty-nine candidate predictors were selected, and the final model for 1-year mortality was developed via multivariate logistic regression and was internally validated by a bootstrapping technique. Results A total of 688 patients were enrolled, and 62 (9.0%) patients died within one year of HD initiation. The following variables were retained in the final model: eGFR, serum albumin, calcium, Charlson Comorbidity Index excluding diabetes and renal disease (modified CCI), performance status (PS), and usage of erythropoiesis-stimulating agent (ESA). Their β-coefficients were transformed into integer scores: three points were assigned to modified CCI3 and PS 3–4; two to calcium>8.5 mg/dL, modified CCI 1–2, and no use of ESA; and one to albumin<3.5 g/dL, eGFR>7 mL/min per 1.73 m2, and PS 1–2. Predicted 1-year mortality risk was 2.5% (score 0–4), 5.5% (score 5–6), 15.2% (score 7–8), and 28.9% (score 9–12). The area under the receiver operating characteristic curve was 0.83 (95% confidence interval, 0.79–0.89). Conclusions We developed a simple 6-item risk score predicting 1-year mortality after the initiation of HD that might help nephrologists make a shared decision with patients and families regarding the initiation of HD.
言語 en
内容記述
内容記述タイプ Other
内容記述 This work was supported by grants from the Institute for Health Outcomes & Process Evaluation research.
出版者
出版者 Public Library of Science
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1371/journal.pone.0129180
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0129180
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1932-6203
開始ページ
開始ページ e0129180
書誌情報 PLoS ONE
PLoS ONE

巻 10, 号 6, p. e0129180, 発行日 2015-06-09
旧ID 47657
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