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Immunological and Regenerative Aspects of Hepatic Mast Cells in Liver Allograft Rejection and Tolerance

https://hiroshima.repo.nii.ac.jp/records/2007948
https://hiroshima.repo.nii.ac.jp/records/2007948
5c9da446-c10c-4e34-869c-ca9e6c39f28d
名前 / ファイル ライセンス アクション
PLoS-One_7_e37202.pdf PLoS-One_7_e37202.pdf (4.6 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Immunological and Regenerative Aspects of Hepatic Mast Cells in Liver Allograft Rejection and Tolerance
言語 en
作成者 Nakano, Toshiaki

× Nakano, Toshiaki

en Nakano, Toshiaki

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Lai, Chia-Yun

× Lai, Chia-Yun

en Lai, Chia-Yun

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Goto, Shigeru

× Goto, Shigeru

en Goto, Shigeru

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Hsu, Li-Wen

× Hsu, Li-Wen

en Hsu, Li-Wen

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Kawamoto, Seiji

× Kawamoto, Seiji

en Kawamoto, Seiji

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Ono, Kazuhisa

× Ono, Kazuhisa

en Ono, Kazuhisa

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Chen, Kuang-Den

× Chen, Kuang-Den

en Chen, Kuang-Den

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Lin, Chih-Che

× Lin, Chih-Che

en Lin, Chih-Che

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Chiu, King-Wah

× Chiu, King-Wah

en Chiu, King-Wah

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Wang, Chih-Chi

× Wang, Chih-Chi

en Wang, Chih-Chi

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Cheng, Yu-Fan

× Cheng, Yu-Fan

en Cheng, Yu-Fan

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Chen, Chao-Long

× Chen, Chao-Long

en Chen, Chao-Long

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 (c) 2012 Nakano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
主題
主題Scheme NDC
主題 490
内容記述
内容記述 The precise roles of mast cells in liver allograft rejection and tolerance are still unknown. This study aimed to explore the roles of mast cells in immune regulation and liver regeneration for tolerance induction by using rat models of orthotopic liver transplantation (OLT).Stem cell factor (SCF) and its receptor c-Kit, which are critical to the migration and development of not only stem cells but also mast cells, significantly increased in the tolerogenic livers as compared with rejected livers. The significant elevation of mast cell tryptase, high-affinity IgE receptor, and histamine suggested the activation of mast cells in liver allografts at the tolerogenic phase after OLT. Immunohistochemical analysis using confocal microscope clearly showed colocalization of mast cells, Foxp3(+) Tregs, gamma delta T cells, and recipient-derived hepatic progenitor cells with higher expression of SCF, IL-9, IL-10, TGF-beta 1, and IL-17 related to immunoregulation and liver regeneration in the donor grafts of a tolerogenic OLT model. Cross-talk among mast cells and other cells was evaluated by in vitro studies demonstrating that syngeneic bone marrow-derived mast cells (BMMCs) co-cultured with naive splenocytes or primary hepatocytes significantly increased the population of splenic gamma delta T cells by mitogen stimulation or by mast cell degranulation, and also significantly induced the hepatocyte proliferation, respectively. Our results suggested that mast cells in the donor grafts may play important roles in the induction/maintenance of immune tolerance and liver regeneration resulting in the replacement of hepatic cells from donor to recipient.
言語 en
出版者
出版者 Public Library of Science
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1371/journal.pone.0037202
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1371/journal.pone.0037202
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1932-6203
開始ページ
開始ページ e37202
書誌情報 PLoS ONE
PLoS ONE

巻 7, 号 5, p. e37202, 発行日 2012
旧ID 34738
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