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Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks

https://hiroshima.repo.nii.ac.jp/records/2007930
https://hiroshima.repo.nii.ac.jp/records/2007930
5db445f4-30e5-4639-b7b9-73e2925cb586
名前 / ファイル ライセンス アクション
PLoS-Genetics_8_e1002440.pdf PLoS-Genetics_8_e1002440.pdf (1.7 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Contribution of Intragenic DNA Methylation in Mouse Gametic DNA Methylomes to Establish Oocyte-Specific Heritable Marks
言語 en
作成者 Kobayashi, Hisato

× Kobayashi, Hisato

en Kobayashi, Hisato

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Sakurai, Takayuki

× Sakurai, Takayuki

en Sakurai, Takayuki

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Imai, Misaki

× Imai, Misaki

en Imai, Misaki

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Takahashi, Nozomi

× Takahashi, Nozomi

en Takahashi, Nozomi

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Fukuda, Atsushi

× Fukuda, Atsushi

en Fukuda, Atsushi

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Obata, Yayoi

× Obata, Yayoi

en Obata, Yayoi

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Sato, Shun

× Sato, Shun

en Sato, Shun

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Nakabayashi, Kazuhiko

× Nakabayashi, Kazuhiko

en Nakabayashi, Kazuhiko

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Hata, Kenichiro

× Hata, Kenichiro

en Hata, Kenichiro

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Sotomaru, Yusuke

× Sotomaru, Yusuke

en Sotomaru, Yusuke

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Suzuki, Yutaka

× Suzuki, Yutaka

en Suzuki, Yutaka

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Kono, Tomohiro

× Kono, Tomohiro

en Kono, Tomohiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 (c) 2012 Kobayashi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Genome-wide dynamic changes in DNA methylation are indispensable for germline development and genomic imprinting in mammals. Here, we report single-base resolution DNA methylome and transcriptome maps of mouse germ cells, generated using whole-genome shotgun bisulfite sequencing and cDNA sequencing (mRNA-seq). Oocyte genomes showed a significant positive correlation between mRNA transcript levels and methylation of the transcribed region. Sperm genomes had nearly complete coverage of methylation, except in the CpG-rich regions, and showed a significant negative correlation between gene expression and promoter methylation. Thus, these methylome maps revealed that oocytes and sperms are widely different in the extent and distribution of DNA methylation. Furthermore, a comparison of oocyte and sperm methylomes identified more than 1,600 CpG islands differentially methylated in oocytes and sperm (germline differentially methylated regions, gDMRs), in addition to the known imprinting control regions (ICRs). About half of these differentially methylated DNA sequences appear to be at least partially resistant to the global DNA demethylation that occurs during preimplantation development. In the absence of Dnmt3L, neither methylation of most oocyte-methylated gDMRs nor intragenic methylation was observed. There was also genome-wide hypomethylation, and partial methylation at particular retrotransposons, while maintaining global gene expression, in oocytes. Along with the identification of the many Dnmt3L-dependent gDMRs at intragenic regions, the present results suggest that oocyte methylation can be divided into 2 types: Dnmt3L-dependent methylation, which is required for maternal methylation imprinting, and Dnmt3L-independent methylation, which might be essential for endogenous retroviral DNA silencing. The present data provide entirely new perspectives on the evaluation of epigenetic markers in germline cells.
言語 en
出版者
出版者 Public Library of Science
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1371/journal.pgen.1002440
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1371/journal.pgen.1002440
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1553-7390
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA12073492
開始ページ
開始ページ e1002440
書誌情報 PLoS Genetics
PLoS Genetics

巻 8, 号 1, p. e1002440, 発行日 2012
旧ID 34741
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