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The induction of insulinomas by X-irradiation to the gastric region in Otsuka Long-Evans Tokushima Fatty rats
https://hiroshima.repo.nii.ac.jp/records/2007905
https://hiroshima.repo.nii.ac.jp/records/2007905fb4b1cbd-ceb9-48bb-99e8-099616aa0545
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
OncolRep_19_987.pdf (208.3 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | The induction of insulinomas by X-irradiation to the gastric region in Otsuka Long-Evans Tokushima Fatty rats | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Watanabe, Hiromitsu
× Watanabe, Hiromitsu
× Kamiya, Kenji
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | Copyright (c) 2008 Spandidos Publications Ltd. | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | insulinoma induction | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | X-irradiation | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Otsuka Long-Evans Tokushima Fatty rat | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | The X-ray induction of tumors was examined in five-week-old male Otsuka Long-Evans Tokushima Fatty (OLETF) rats, treated with two 10 Gy doses to the gastric region with a 3-day interval (total 20 Gy). After irradiation, the rats received the commercial diet MF and tap water and were maintained for up to 564 days. The mean serum glucose level in the X-irradiated group was significantly lower than that in the non-irradiated animals at the 18 month time point. The total tumor incidence was 27/30 (87.1%) in the treated rats (islet tumors, gastric tumors, sarcomas, seminomas, adrenal tumors, kidney tumors, papilloma, lymphomas and mammary tumors). Islet tumors, generally showed to be positive for insulin by immunohistochemistry, developed in 19 rats (63.3%), and were associated with low serum glucose. Since spontaneous tumors observed in 6/19 (31.6%) rats (sarcomas, kidney tumors, duodenum tumors, seminoma, adrenal tumor and squamous cell carcinoma) did not include any insulinomas, these are clearly induced by X-irradiation in OLETF rats. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Spandidos Publications Ltd. | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1021-335X | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11016405 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 987 | |||||||||
| 書誌情報 |
Oncology Reports Oncology Reports 巻 19, 号 4, p. 987-991, 発行日 2008-04 |
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| 旧ID | 31174 | |||||||||
