| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
μ-Opioid receptor agonist diminishes POMC gene expression and anorexia by central insulin in neonatal chicks |
|
言語 |
en |
| 作成者 |
Shiraishi, Jun-ichi
Yanagita, Kouichi
Fujita, Masanori
Bungo, Takashi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2008 Elsevier Ireland Ltd |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
β-Endorphin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
food intake |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
insulin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
central nervous system |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
neonatal chick |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
melanocortin system |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
480 |
| 内容記述 |
|
|
内容記述 |
Pro-opiomelanocortin (POMC) neurons in the hypothalamus are direct targets of peripheral satiety signals, such as leptin and insulin in mammals. The stimulation of these signals activates hypothalamic POMC neurons and elevates POMC-derived melanocortin peptides that inhibit food intake in mammals. On the other hand, it has been recognized that β-endorphin, a post-translational processing of POMC, acts in an autoreceptor manner to the μ-opioid receptor (MOR) on POMC neurons, diminishing POMC neuronal activity in mammals. Recently, we found that central insulin functions as an anorexic peptide in chicks. Thus, the present study was done to elucidate whether β-endorphin affects the activation of POMC neurons by insulin in neonatal chicks. Consequently, quantitative real-time PCR analysis shows that intracerebroventricular (ICV) injection of insulin with β-endorphin significantly decreases brain POMC mRNA expression when compared with insulin alone. In addition, co-injection of MOR agonist (β-endorphin or [d-Ala2, N-MePhe4, Gly5-ol]-enkephalin (DAMGO)) significantly attenuates insulin-induced hypophagia in chicks. These data suggest that β-endorphin regulates the activity of the central melanocortin system, and its activation may provide an inhibitory feedback mechanism in the brain of neonatal chicks. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Ireland Ltd |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.neulet.2008.05.040 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.neulet.2008.05.040 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0304-3940 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00754925 |
| 開始ページ |
|
|
開始ページ |
227 |
| 書誌情報 |
Neuroscience Letters
Neuroscience Letters
巻 439,
号 3,
p. 227-229,
発行日 2008-07
|
| 旧ID |
25588 |
NSL_439_227.pdf (301.6 KB)
