| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Effects of single prolonged stress and D-cycloserine on contextual fear extinction and hippocampal NMDA receptor expression in a rat model of PTSD |
|
言語 |
en |
| 作成者 |
Yamamoto, Shigeto
Morinobu, Shigeru
Fuchikami, Manabu
Kurata, Akiko
Kozuru, Toshiro
Yamawaki, Shigeto
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 American College of Neuropsychopharmacology |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
posttraumatic stress disorder (PTSD) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
single prolonged stress (SPS) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
extinction |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
contextual fear conditioning |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
NMDA receptor subunits (NMDARs) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
D-cycloserine (DCS) |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
140 |
| 内容記述 |
|
|
内容記述 |
Although the impaired extinction of traumatic memory is one of the hallmark symptoms of PTSD, the underlying mechanisms of impaired extinction are unclear and effective pharmacological interventions have not yet been developed. Single prolonged stress (SPS) has been proposed as an animal model of PTSD, since rats subjected to SPS (SPS rats) show enhanced negative feedback of the HPA axis and increased contextual fear, which are characteristics similar to those observed in patients with PTSD. In this study, using SPS rats, we examined (a) the ability of SPS to impair fear extinction, (b) whether D-cycloserine (DCS) can alleviate impaired fear extinction in SPS rats, and (c) the effect of SPS and/or DCS on the levels of N-methyl-D-aspartate (NMDA) receptor subunit mRNAs in the rat hippocampus during extinction training. SPS rats exhibited impaired fear extinction in the contextual fear test, which was alleviated by the repeated administration of DCS. The effect of enhanced extinction, induced by the administration of DCS to SPS rats, was maintained for one week following extinction training. SPS induced significant upregulation of the levels of NMDA receptor subunit mRNAs before and during the period of extinction training, while repeated administration of DCS eliminated the enhanced mRNA levels of NMDARs. Behavioral analyses indicated that SPS is an appropriate animal model of PTSD and that DCS may be effective in the treatment of PTSD. These findings suggest that DCS, irrespective of its mechanistic involvement in the enhancement of fear extinction, may help to reverse hippocampal plasticity, and thus reverse the NMDA compensatory alterations. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nature Publishing Group |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/sj.npp.1301605 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1038/sj.npp.1301605 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0893-133X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10761483 |
| 開始ページ |
|
|
開始ページ |
2108 |
| 書誌情報 |
Neuropsychopharmacology
Neuropsychopharmacology
巻 33,
号 9,
p. 2108-2116,
発行日 2008
|
| 旧ID |
25924 |
Neuropsychopharmacology_33_2108.pdf (277.7 KB)
