| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model |
|
言語 |
en |
| 作成者 |
Takahashi, Shunsuke
Taniguchi, Yoshihiko
Nakashima, Ayumu
Arakawa, Tetsuji
Kawai, Toru
Doi, Shigehiro
Ito, Takafumi
Masaki, Takao
Kohno, Nobuoki
Yorioka, Noriaki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 S. Karger AG, Basel |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Macrophage |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Mizoribine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Peritoneal dialysis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Peritoneal fibrosis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Experimental peritoneal fibrosis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
rat model |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Background/Aims: Peritoneal fibrosis is a serious complication of peritoneal dialysis (PD). It has been reported that administration of mizoribine, an effective immunosuppressant, ameliorated renal fibrosis in a rat model of unilateral ureteral obstruction. We therefore examined the effects of mizoribine in an experimental model of peritoneal fibrosis. Methods: 24 rats were given a daily intraperitoneal injection of chlorhexidine gluconate and ethanol dissolved in saline. The rats were divided into three groups (n = 8 per group) that received either vehicle or mizoribine at a dose of 2 or 8 mg/kg once a day. 28 days after the start of the treatments the rats were sacrificed and peritoneal tissue samples collected. Macrophage infiltration (ED1), myofibroblast accumulation (alpha-smooth muscle actin (SMA)) and expression of type III collagen, transforming growth factor (TGF)-beta and monocyte chemotactic protein-1 (MCP-1) were examined by immunohistochemistry. Results: Mizoribine significantly suppressed submesothelial zone thickening and reduced macrophage infiltration. Mizoribine also reduced collagen III+ area and decreased the number of alpha-SMA(+), TGF-beta(+) and MCP-1(+) cells. The magnitude of the changes observed was dose-dependent. Conclusion: The administration of mizoribine prevented the progression of peritoneal fibrosis in this rat model. Mizoribine may represent a novel therapy for peritoneal sclerosis in patients undergoing long-term PD. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Karger |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1159/000213896 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1159/000213896 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1660-2129 |
| 開始ページ |
|
|
開始ページ |
E59 |
| 書誌情報 |
Nephron Experimental Nephrology
Nephron Experimental Nephrology
巻 112,
号 2,
p. E59-E69,
発行日 2009
|
| 旧ID |
27694 |
NephronExpNephrol_112_E59.pdf (1.2 MB)
