| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Drosophila Strip serves as a platform for early endosome organization during axon elongation |
|
言語 |
en |
| 作成者 |
Sakuma, Chisako
Kawauchi, Takeshi
Haraguchi, Shuka
Shikanai, Mima
Yamaguchi, Yoshifumi
Gelfand, Vladimir I
Luo, Liqun
Miura, Masayuki
Chihara, Takahiro
|
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
© 2014 Macmillan Publishers Limited. |
| 内容記述 |
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|
内容記述 |
Early endosomes are essential for regulating cell signalling and controlling the amount of cell surface molecules during neuronal morphogenesis. Early endosomes undergo retrograde transport (clustering) before their homotypic fusion. Small GTPase Rab5 is known to promote early endosomal fusion, but the mechanism linking the transport/clustering with Rab5 activity is unclear. Here we show that Drosophila Strip is a key regulator for neuronal morphogenesis. Strip knockdown disturbs the early endosome clustering, and Rab5-positive early endosomes become smaller and scattered. Strip genetically and biochemically interacts with both Glued (the regulator of dynein-dependent transport) and Sprint (the guanine nucleotide exchange factor for Rab5), suggesting that Strip is a molecular linker between retrograde transport and Rab5 activation. Overexpression of an active form of Rab5 in strip-mutant neurons suppresses the axon elongation defects. Thus, Strip acts as a molecular platform for the early endosome organization that has important roles in neuronal morphogenesis. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by grants from the National Institute of General Medical Science of the National Institutes of Health (R01-GM085232 to V.I.G.), the National Institutes of Health (R01-DC005982 to L.L.), the Japanese Ministry of Education, Science, Sports, Culture, and Technology (MEXT), the Japan Society for the Promotion of Science, and the Japan Science and Technology Agency (to C.S., K.T., Y.Y., M.M., and T.C.). |
| 出版者 |
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出版者 |
Nature Publishing Group |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/ncomms6180 |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/ncomms6180 |
| 関連情報 |
|
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
25312435 |
| 収録物識別子 |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2041-1723 |
| 開始ページ |
|
|
開始ページ |
5180 |
| 書誌情報 |
Nature Communications
Nature Communications
巻 5,
p. 5180,
発行日 2014-10-14
|
| 旧ID |
48723 |
NatCommun_5_5180.pdf (4.0 MB)
