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Direct binding of RalA to PKC eta and its crucial role in morphological change during keratinocyte differentiation

https://hiroshima.repo.nii.ac.jp/records/2007744
https://hiroshima.repo.nii.ac.jp/records/2007744
7fec4133-6771-449f-b168-00c69fb165cd
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MolBiolCell_22_1340.pdf MolBiolCell_22_1340.pdf (2.9 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Direct binding of RalA to PKC eta and its crucial role in morphological change during keratinocyte differentiation
言語 en
作成者 Shirai, Yasuhito

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en Shirai, Yasuhito

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Morioka, Shoko

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en Morioka, Shoko

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Sakuma, Megumi

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en Sakuma, Megumi

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Yoshino, Ken-ichi

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Otsuji, Chihiro

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en Otsuji, Chihiro

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Sakai, Norio

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Kashiwagi, Kaori

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en Kashiwagi, Kaori

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Chida, Kazuhiro

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Shirakawa, Ryutaro

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Horiuchi, Hisanori

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Nishigori, Chikako

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Ueyama, Takehiko

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en Ueyama, Takehiko

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Saito, Naoaki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2011 Shirai et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution-Noncommercial-Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).
主題
主題Scheme NDC
主題 490
内容記述
内容記述 During differentiation, keratinocytes undergo a dramatic shape change from small and round to large and flat, in addition to production of proteins necessary for the formation of epidermis. It has been shown that protein kinase C (PKC) η is crucial for keratinocyte differentiation. However, its role in this process has yet to be fully elucidated. Here, we show that catalytic activity is not necessary for enlarged and flattened morphology of human keratinocytes induced by overexpression of PKCη, although it is important for gene expression of the marker proteins. In addition, we identify the small G protein RalA as a binding partner of PKCη, which binds to the C1 domain, an indispensable region for the morphological change. The binding led activation of RalA and actin depolymerization associated with keratinocyte differentiation. siRNA techniques proved that RalA is involved in not only the keratinocyte differentiation induced by PKCη overexpression but also normal keratinocyte differentiation induced by calcium and cholesterol sulfate. These results provide a new insight into the molecular mechanism of cytoskeletal regulation leading to drastic change of cell shape.
言語 en
出版者
出版者 The American Society for Cell Biology
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1091/mbc.E10-09-0754
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1091/mbc.E10-09-0754
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA12024500
開始ページ
開始ページ 1340
書誌情報 Molecular biology of the cell
Molecular biology of the cell

巻 22, 号 8, p. 1340-1352, 発行日 2011-02-23
旧ID 32028
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