| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach |
|
言語 |
en |
| 作成者 |
Sentani, Kazuhiro
Oue, Naohide
Sakamoto, Naoya
Arihiro, Koji
Aoyagi, Kazuhiro
Sasaki, Hiroki
Yasui, Wataru
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2008 USCAP, Inc |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hepatoid adenocarcinoma |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hepatocellular carcinoma |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
PLUNC |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
microarray |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
SAGE |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
gastric cancer |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Gastric cancer is one of the most common malignancies worldwide. In this study, we screened for genes upregulated in gastric cancer by comparing gene expression profiles from serial analysis of gene expression and microarray and identified the palate, lung, and nasal epithelium carcinoma-associated protein (PLUNC) gene. Immunostaining for PLUNC in 140 gastric cancer cases revealed strong and extensive staining of PLUNC in hepatoid adenocarcinoma of the stomach, whereas 727777677340f conventional gastric cancer cases showed focal immunostaining of PLUNC. Gastric hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphologic similarities to hepatocellular carcinoma. To investigate the utility of PLUNC immunostaining in the diagnosis of gastric hepatoid adenocarcinoma, six cases of gastric hepatoid adenocarcinoma (six primary tumors and two associated liver metastases) were studied further. PLUNC staining was observed in all six primary hepatoid adenocarcinomas. PLUNC staining was observed in both the hepatoid adenocarcinoma and tubular/papillary adenocarcinoma components of primary tumors, although PLUNC staining was preferentially localized in tubular/papillary adenocarcinoma components. Staining of PLUNC was also detected in both liver metastases. PLUNC staining was not observed in 52 cases of primary hepatocellular carcinoma or in normal adult or fetal liver. These results indicate that PLUNC is a novel marker that distinguishes gastric hepatoid adenocarcinoma from primary hepatocellular carcinoma. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nature Publishing Group |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/modpathol.3801050 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
18204429 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1038/modpathol.3801050 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1067307X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0893-3952 |
| 開始ページ |
|
|
開始ページ |
464 |
| 書誌情報 |
Modern Pathology
Modern Pathology
巻 21,
号 4,
p. 464-475,
発行日 2008-04
|
| 旧ID |
24603 |
ModPathol_21_464.pdf (7.4 MB)
