| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
The impact of visceral adipose tissue and high-molecular weight adiponectin on cardio-ankle vascular index in asymptomatic Japanese subjects |
|
言語 |
en |
| 作成者 |
Ohashi, Norihiko
Ito, Chikako
Fujikawa, Rumi
Yamamoto, Hideya
Kihara, Yasuki
Kohno, Nobuoki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 Elsevier Inc. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
visceral adipose tissue (VAT) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
high-molecular weight (HMW) adiponectin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
metabolic syndrome (MetS) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cardio-ankle vascular index (CAVI) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
arterial stiffness |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Few studies addressed the relation of visceral adiposity and high-molecular weight (HMW) adiponectin to arterial stiffness. We investigated the impact of visceral adipose tissue (VAT) and HMW adiponectin on cardio-ankle vascular index (CAVI) in asymptomatic Japanese subjects. We studied 487 consecutive subjects (271 men and 216 women) who underwent general health examination between October 2005 and May 2008. The abdominal, visceral, and subcutaneous adipose tissue areas were determined by low-dose x-ray computed tomography. Serum levels of total and HMW adiponectin were measured using the enzyme-linked immunosorbent assay system based on a monoclonal antibody to humans. Cardio-ankle vascular index was positively correlated with VAT area and negatively correlated with HMW adiponectin levels. We also found the positive association of the number of metabolic syndrome components with CAVI in both sexes. A stepwise multiple regression analysis revealed that age, VAT area, serum HMW adiponectin levels, and homeostasis model assessment of insulin resistance were independent determinants of CAVI. Receiver operating characteristic analyses demonstrated that the predictive value of the VAT area for the extent of CAVI (mild: <25th percentile vs severe: >75th percentile) exceeded that of total or HMW adiponectin levels in both sexes. In conclusion, increased CAVI is associated with both amounts of VAT measured by computed tomography and serum HMW adiponectin levels in asymptomatic Japanese subjects. Receiver operating characteristic analysis indicates that the VAT area is a lot better predictor of arterial stiffness than adiponectin levels. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
W B Saunders CO-Eleevier Inc |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.metabol.2009.03.005 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.metabol.2009.03.005 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0026-0495 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0073583X |
| 開始ページ |
|
|
開始ページ |
1023 |
| 書誌情報 |
Metabolism-Clinical and Experimental
Metabolism-Clinical and Experimental
巻 58,
号 7,
p. 1023-1029,
発行日 2009
|
| 旧ID |
27757 |
Metabol_58_1023.pdf (295.4 KB)
