| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: Preferential localization of claudin-4 at the apex of the dome region |
|
言語 |
en |
| 作成者 |
Tamagawa, Hiroshi
Takahashi, Ichiro
Furuse, Mikio
Yoshitake, Yuka
Tsukita, Shoichiro
Itoh, Toshinori
Matsuda, Hikaru
Kiyono, Hiroshi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2003 United States and Canadian Academy of Pathology |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
claudin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
follicle-associated epithelium |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
occludin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Peyer's patch |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
tight junction |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Gut-associated lymphoreticular tissue (GALT), such as Peyer's patches (PP) and cecal patches, are important inductive sites for mucosal immune responses. As such, the GALT may have an epithelial barrier different from that of villous epithelium. In this study, we investigated the immunohistochemical distribution of the claudin family and occludin in the follicle-associated epithelium (FAE) of Peyer's patches and cecal patches of murine intestine. Unique profiles of claudin-2, -3, -4 and occludin expression were noted in the tight junctions of the FAE: claudin-4 was preferentially expressed in the apex region; claudin-2 was only weakly expressed on the crypt side of the FAE compared to stronger expression on the crypt side of villous epithelial cells; claudin-3 and occludin were found throughout the dome. These unique expression patterns were present also in cecal patch FAE. We also found that claudin-4 expression in the FAE of Peyer's patches and cecal patches corresponded with the presence of TUNEL-positive apoptotic cells, and Peyer's patch-deficient mice had expression patterns of claudin and occludin in villous epithelia similar to those in wild-type mice. We conclude that claudin-4 expression is preferentially associated with the dome region of FAE, the mucosal inductive site of the murine intestine. In that location and it might correlate with the cell life cycle, help maintain the apex configuration of the dome, or be a factor favoring the uptake of antigens by the FAE. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nature Publishing Group |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1097/01.LAB.0000078741.55670.6E |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
12861044 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1097/01.LAB.0000078741.55670.6E |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0023-6837 |
| 開始ページ |
|
|
開始ページ |
1045 |
| 書誌情報 |
Laboratory investigation
Laboratory investigation
巻 83,
号 7,
p. 1045-1053,
発行日 2003-07
|
| 旧ID |
109 |
Lab-Invest_83-7_1045-53_2003-7.pdf (716.1 KB)
