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Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: Preferential localization of claudin-4 at the apex of the dome region

https://hiroshima.repo.nii.ac.jp/records/2007631
https://hiroshima.repo.nii.ac.jp/records/2007631
3bb25ee3-1d01-49f8-a2e5-279b1a839d86
名前 / ファイル ライセンス アクション
Lab-Invest_83-7_1045-53_2003-7.pdf Lab-Invest_83-7_1045-53_2003-7.pdf (716.1 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: Preferential localization of claudin-4 at the apex of the dome region
言語 en
作成者 Tamagawa, Hiroshi

× Tamagawa, Hiroshi

en Tamagawa, Hiroshi

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Takahashi, Ichiro

× Takahashi, Ichiro

en Takahashi, Ichiro

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Furuse, Mikio

× Furuse, Mikio

en Furuse, Mikio

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Yoshitake, Yuka

× Yoshitake, Yuka

en Yoshitake, Yuka

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Tsukita, Shoichiro

× Tsukita, Shoichiro

en Tsukita, Shoichiro

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Itoh, Toshinori

× Itoh, Toshinori

en Itoh, Toshinori

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Matsuda, Hikaru

× Matsuda, Hikaru

en Matsuda, Hikaru

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Kiyono, Hiroshi

× Kiyono, Hiroshi

en Kiyono, Hiroshi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2003 United States and Canadian Academy of Pathology
主題
主題Scheme Other
主題 claudin
主題
主題Scheme Other
主題 follicle-associated epithelium
主題
主題Scheme Other
主題 occludin
主題
主題Scheme Other
主題 Peyer's patch
主題
主題Scheme Other
主題 tight junction
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Gut-associated lymphoreticular tissue (GALT), such as Peyer's patches (PP) and cecal patches, are important inductive sites for mucosal immune responses. As such, the GALT may have an epithelial barrier different from that of villous epithelium. In this study, we investigated the immunohistochemical distribution of the claudin family and occludin in the follicle-associated epithelium (FAE) of Peyer's patches and cecal patches of murine intestine. Unique profiles of claudin-2, -3, -4 and occludin expression were noted in the tight junctions of the FAE: claudin-4 was preferentially expressed in the apex region; claudin-2 was only weakly expressed on the crypt side of the FAE compared to stronger expression on the crypt side of villous epithelial cells; claudin-3 and occludin were found throughout the dome. These unique expression patterns were present also in cecal patch FAE. We also found that claudin-4 expression in the FAE of Peyer's patches and cecal patches corresponded with the presence of TUNEL-positive apoptotic cells, and Peyer's patch-deficient mice had expression patterns of claudin and occludin in villous epithelia similar to those in wild-type mice. We conclude that claudin-4 expression is preferentially associated with the dome region of FAE, the mucosal inductive site of the murine intestine. In that location and it might correlate with the cell life cycle, help maintain the apex configuration of the dome, or be a factor favoring the uptake of antigens by the FAE.
言語 en
出版者
出版者 Nature Publishing Group
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
関連情報
識別子タイプ DOI
関連識別子 10.1097/01.LAB.0000078741.55670.6E
関連情報
識別子タイプ PMID
関連識別子 12861044
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1097/01.LAB.0000078741.55670.6E
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0023-6837
開始ページ
開始ページ 1045
書誌情報 Laboratory investigation
Laboratory investigation

巻 83, 号 7, p. 1045-1053, 発行日 2003-07
旧ID 109
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