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Intestinal Metaplasia : The Effect of Acid on the Gastric Mucosa and Gastric Carcinogenesis
https://hiroshima.repo.nii.ac.jp/records/2007621
https://hiroshima.repo.nii.ac.jp/records/2007621e5a0abde-6130-4fad-834b-4a7f526f5533
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JToxicolPathol_23_115.pdf (298.4 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Intestinal Metaplasia : The Effect of Acid on the Gastric Mucosa and Gastric Carcinogenesis | |||||||
| 言語 | en | |||||||
| 作成者 |
Watanabe, Hiromitsu
× Watanabe, Hiromitsu
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利情報 | ||||||||
| 権利情報 | Copyright (c) 2010 The Japanese Society of Toxicologic Pathology | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | X-irradiation | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | rat | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | glandular stomach | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | intestinal metaplasia | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | gastric cancer | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | This review concerns stem cells and their relation to intestinal metaplasia. When gastric regions of mice, Mongolian gerbils or several strains of rats were irradiated with a total dose of 20 Gy of X-rays given in two fractions, intestinal metaplasia was only induced in rats. In addition, it was greatly influenced by rat strain and sex. Alkaline phosphatase (ALP) positive metaplastic foci were increased by administration of ranitidine (H2 receptor antagonist), crude stomach antigens or subtotal resection of the fundus and decreased by cysteamine (gastric acid secretion stimulator), histamine or removal of the submandibular glands. Recent studies have shown that Cdx2 transgenic mice with gastric achlorhydria develop intestinal metaplasia and that in men and animals, Helicobacter pylori (H. pyrlori) infection can cause intestinal metaplasias that are reversible on eradication. Our results combined with findings for H. pylori infection or eradication and transgenic mice suggest that an elevation in the pH of the gastric juice due to disappearance of parietal cells is one of the principal factors for development of reversible intestinal metaplasia. When different organs were transplanted into the stomach or duodenum, they were found to transdifferentiate into gastric or duodenal mucosae, respectively. Organ-specific stem cells in normal non-liver tissues (heart, kidney, brain and skin) also differentiate into hepatocytes when transplanted into an injured liver. Therefore, stem cells have a multipotential ability, transdifferentiating into different organs when transplanted into different environments. Finally, intestinal metaplasia has been found to possibly increase sensitivity to the induction of tumors by colon carcinogens of the 1,2-dimethylhydrazine (DMH), azoxymethane (AOM) or 2-amino-1-methyl-6-phenylimidazo[4.5-b]pyridine (PhIP) type. This carcinogenic process, however, may be relatively minor compared with the main gastric carcinogenesis process induced by N-methy1-N'-nitro-N-nitrosoguanidine (MMNG) or N-met | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | 日本毒性病理学会 | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1293/tox.23.115 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | http://dx.doi.org/10.1293/tox.23.115 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0914-9198 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AN10232280 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 115 | |||||||
| 書誌情報 |
Journal of toxicologic pathology Journal of toxicologic pathology 巻 23, 号 3, p. 115-123, 発行日 2010 |
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| 旧ID | 30955 | |||||||
