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Intestinal Metaplasia : The Effect of Acid on the Gastric Mucosa and Gastric Carcinogenesis

https://hiroshima.repo.nii.ac.jp/records/2007621
https://hiroshima.repo.nii.ac.jp/records/2007621
e5a0abde-6130-4fad-834b-4a7f526f5533
名前 / ファイル ライセンス アクション
JToxicolPathol_23_115.pdf JToxicolPathol_23_115.pdf (298.4 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Intestinal Metaplasia : The Effect of Acid on the Gastric Mucosa and Gastric Carcinogenesis
言語 en
作成者 Watanabe, Hiromitsu

× Watanabe, Hiromitsu

en Watanabe, Hiromitsu

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2010 The Japanese Society of Toxicologic Pathology
主題
主題Scheme Other
主題 X-irradiation
主題
主題Scheme Other
主題 rat
主題
主題Scheme Other
主題 glandular stomach
主題
主題Scheme Other
主題 intestinal metaplasia
主題
主題Scheme Other
主題 gastric cancer
主題
主題Scheme NDC
主題 490
内容記述
内容記述 This review concerns stem cells and their relation to intestinal metaplasia. When gastric regions of mice, Mongolian gerbils or several strains of rats were irradiated with a total dose of 20 Gy of X-rays given in two fractions, intestinal metaplasia was only induced in rats. In addition, it was greatly influenced by rat strain and sex. Alkaline phosphatase (ALP) positive metaplastic foci were increased by administration of ranitidine (H2 receptor antagonist), crude stomach antigens or subtotal resection of the fundus and decreased by cysteamine (gastric acid secretion stimulator), histamine or removal of the submandibular glands. Recent studies have shown that Cdx2 transgenic mice with gastric achlorhydria develop intestinal metaplasia and that in men and animals, Helicobacter pylori (H. pyrlori) infection can cause intestinal metaplasias that are reversible on eradication. Our results combined with findings for H. pylori infection or eradication and transgenic mice suggest that an elevation in the pH of the gastric juice due to disappearance of parietal cells is one of the principal factors for development of reversible intestinal metaplasia. When different organs were transplanted into the stomach or duodenum, they were found to transdifferentiate into gastric or duodenal mucosae, respectively. Organ-specific stem cells in normal non-liver tissues (heart, kidney, brain and skin) also differentiate into hepatocytes when transplanted into an injured liver. Therefore, stem cells have a multipotential ability, transdifferentiating into different organs when transplanted into different environments. Finally, intestinal metaplasia has been found to possibly increase sensitivity to the induction of tumors by colon carcinogens of the 1,2-dimethylhydrazine (DMH), azoxymethane (AOM) or 2-amino-1-methyl-6-phenylimidazo[4.5-b]pyridine (PhIP) type. This carcinogenic process, however, may be relatively minor compared with the main gastric carcinogenesis process induced by N-methy1-N'-nitro-N-nitrosoguanidine (MMNG) or N-met
言語 en
出版者
出版者 日本毒性病理学会
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1293/tox.23.115
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1293/tox.23.115
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0914-9198
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AN10232280
開始ページ
開始ページ 115
書誌情報 Journal of toxicologic pathology
Journal of toxicologic pathology

巻 23, 号 3, p. 115-123, 発行日 2010
旧ID 30955
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