| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody |
|
言語 |
en |
| 作成者 |
Abou Elazab, Mohamed Fahmy
Fukushima, Yuji
Fujita, Yukihiro
Horiuchi, Hiroyuki
Matsuda, Haruo
Furusawa, Shuichi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2010 社団法人日本獣医学会 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
antigen specificity |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chick |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
IgY |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
maternal antibody |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
suppression |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
480 |
| 内容記述 |
|
|
内容記述 |
Prolonged interference or suppression of maternal antibodies of the humoral immune response of newly hatched chicks to active immunization has been documented; however, the immunological mechanisms responsible for such suppression are still unclear. Laying hens were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH). Purified maternal anti-DNP or non-specificIgY antibodies were transferred by yolk sac inoculation to newly hatched chicks, and they were immunized with DNP-KLH or rabbit serum albumen (RSA) at 1 and 4 weeks of age. The concentrations of anti-DNP and anti-RSA antibodies in serum samples of these chicks were measured using an enzyme-linked immunosorbent assay (ELISA). The immune responses of the chicks that received a high dose of maternal anti-DNP antibodies and were immunized with an appropriate dose of DNP-KLH were suppressed. However, those of the chicks that received the same high dose of maternal non-specific IgY antibodies and were immunized with an appropriate dose of DNP-KLH and those of the chicks that received a high dose of maternal anti-DNP antibodies and were immunized with RSA were not suppressed. On the other hand, suppression of anti-DNP antibody production would not be induced if the chicks received a high dose of antigen specific maternal antibodies and were immunized with a high dose of the same antigen. These results revealed that the immune suppressive effect of maternal antibodies on the immune response of the newly hatched chicks was antigen specific and depended mainly on the ratio of antigen/maternal antibody at the time of immunization. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Society of Veterinary Science |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1292/jvms.09-0298 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1292/jvms.09-0298 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0916-7250 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10796138 |
| 開始ページ |
|
|
開始ページ |
257 |
| 書誌情報 |
Journal of Veterinary Medical Science
Journal of Veterinary Medical Science
巻 72,
号 3,
p. 257-262,
発行日 2010
|
| 旧ID |
30401 |
JVetMedSci_72_257.pdf (279.0 KB)
