| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts |
|
言語 |
en |
| 作成者 |
Fujita, Tsuyoshi
Iwata, Tomoyuki
Shiba, Hideki
Igarashi, Akira
Hirata, Reika
Takeda, Katsuhiro
Mizuno, Noriyuki
Tsuji, Koichiro
Kawaguchi, Hiroyuki
Kato, Yukio
Kurihara, Hidemi
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright (c) 2006 The Authors ; Journal compilation (c) 2006 Blackwell Munksgaard |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
human periodontal ligament cells |
| 主題 |
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主題Scheme |
Other |
|
主題 |
molecular gene marker |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
apolipoprotein D |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
MHC-DR-α |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
MHC-DR-β |
| 主題 |
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|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
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|
内容記述 |
Background and Objective: Molecular gene markers, which can distinguish human bone marrow mesenchymal stem cells from human fibroblasts, have recently been reported. Messenger RNA levels of tissue factor pathway inhibitor-2, major histocompatibility complex-DR-α, major histocompatibility complex-DR-β, and neuroserpin are higher in human bone marrow mesenchymal stem cells than in human fibroblasts. However, human bone marrow mesenchymal stem cells express less apolipoprotein D mRNA than human fibroblasts. Periodontal ligament cells are a heterogeneous cell population including fibroblasts, mesenchymal stem cells, and progenitor cells of osteoblasts or cementoblasts. The use of molecular markers that distinguish human bone marrow mesenchymal stem cells from human fibroblasts may provide insight into the characteristics of human periodontal ligament cells. In this study, we compared the molecular markers of human periodontal ligament cells with those of human bone marrow mesenchymal stem cells and human gingival fibroblasts.Material and Methods: The mRNA expression of the molecular gene markers was analyzed using real-time polymerase chain reaction. Statistical differences were determined with the two-sided Mann–Whitney U-test.Results: Messenger RNA levels of major histocompatibility complex-DR-α and major histocompatibility complex-DR-β were lower and higher, respectively, in human periodontal ligament cells than in human bone marrow mesenchymal stem cells or human gingival fibroblasts. Human periodontal ligament cells showed the lowest apolipoprotein D mRNA levels among the three types of cells.Conclusion: Human periodontal ligament cells may be distinguished from human bone marrow mesenchymal stem cells and human gingival fibroblasts by the genes for apolipoprotein D, major histocompatibility complex-DR-α, and major histocompatibility complex-DR-β. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1111/j.1600-0765.2006.00944.x |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1111/j.1600-0765.2006.00944.x |
| 開始ページ |
|
|
開始ページ |
283 |
| 書誌情報 |
Journal of Periodontal Research
Journal of Periodontal Research
巻 42,
号 3,
p. 283-286,
発行日 2007-06
|
| 旧ID |
22759 |
JPeriodontalRes_42_283.pdf (122.0 KB)
