| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2025-01-10 |
| タイトル |
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|
タイトル |
MicroRNA-26a deficiency attenuates the severity of frozen shoulder in a mouse immobilization model |
|
言語 |
en |
| 作成者 |
Sumimoto, Yasuhiko
Harada, Yohei
Yimiti, Dilimulati
Watanabe, Chikara
Miyaki, Shigeru
Adachi, Nobuo
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利情報 |
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言語 |
en |
|
権利情報 |
This is the peer reviewed version of the following article: Journal of Orthopaedic Research, 42(12), 2623-2633, MicroRNA-26a deficiency attenuates the severity of frozen shoulder in a mouse immobilization model, Yasuhiko Sumimoto, Yohei Harada, Dilimulati Yimiti, Chikara Watanabe, Shigeru Miyaki, Nobuo Adachi, which has been published in final form at https://doi.org/10.1002/jor.25940. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
fibrosis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
frozen shoulder |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inflammation |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
knockout mice |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
microRNA-26a |
| 内容記述 |
|
|
内容記述 |
The main pathogenesis of the frozen shoulder is thought to be the inflammation of the intra-articular synovium and subsequent fibrosis of the shoulder joint capsule. However, the molecular pathogenesis of the frozen shoulder is still unknown. A class of noncoding RNAs, microRNAs contribute to various diseases including musculoskeletal diseases. MicroRNA-26a (miR-26a) has been reported to be associated with fibrosis in several organs. This study aims to reveal the role of miR-26a on fibrosis in the shoulder capsule using a frozen shoulder model in miR-26a deficient (miR-26a KO) mice. MiR-26a KO and wild-type (WT) mice were investigated using a frozen shoulder model. The range of motion (ROM) of the shoulder, histopathological changes such as synovitis, and fibrosis-related gene expression in the model mice were evaluated to determine the role of miR-26a. In WT mice, both inflammatory cell infiltration and thickening of the inferior shoulder joint capsule were observed after 1 week of immobilization, and this thickening further progressed over the subsequent 6 weeks. However, the immobilized shoulder in miR-26a KO mice consistently exhibited significantly better ROM compared with WT mice at 1 and 6 weeks, and histological changes were significantly less severe. The expression of inflammation- and fibrosis-related genes was decreased in the miR-26a KO mice compared with WT mice at 1 and 6 weeks. Together, miR-26a deficiency attenuated the severity of frozen shoulder in the immobilization model mouse. The present study suggests that miR-26a has the potential to be a target miRNA for therapeutic approach to frozen shoulder. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1002/jor.25940 |
| 助成情報 |
|
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助成機関名 |
日本学術振興会 |
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言語 |
ja |
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研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21K16687/ |
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|
研究課題番号 |
21K16687 |
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研究課題名 |
microRNAを標的とした凍結肩の病態解明と新たな治療戦略 |
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言語 |
ja |
| 助成情報 |
|
|
|
助成機関名 |
Japan Society for the Promotion of Science |
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|
言語 |
en |
|
|
研究課題名 |
microRNAを標的とした凍結肩の病態解明と新たな治療戦略 |
|
|
言語 |
ja |
| 開始ページ |
|
|
開始ページ |
2623 |
| 書誌情報 |
en : Journal of Orthopaedic Research
巻 42,
号 12,
p. 2623-2633,
発行日 2024-07-22
|
| 旧ID |
56099 |
| 備考 |
The full-text file will be made open to the public on 22 July 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
JOR_42_2623.pdf (1.4 MB)
