| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Docosahexaenoic- and Eicosapentaenoic Acid-bound Lysophospholipids are More Effective in Suppressing Angiogenesis than Conjugated Docosahexaenoic Acid |
|
言語 |
en |
| 作成者 |
Tsushima, Tadahiro
Matsubara, Kiminori
Ohkubo, Takeshi
Inoue, Yoshikazu
Takahashi, Koretaro
|
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2012 by Japan Oil Chemists' Society |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
angiogenesis |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
phospholipids |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
lysophospholipids |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
omega 3 |
| 内容記述 |
|
|
内容記述 |
Suppression of leukemia, colon cancer, myeloma, and fibrosarcoma to some extent by omega 3 fatty acid bound phospholipids has been reported in the last two decade. However, the anti-angiogenic activity of those phospholipids is still not known. Four kinds of marine phospholipid molecular species i.e. starfish EPA bound diacyl phospholipid (EPA-PC), EPA bound monoacyl phospholipid (EPA-LPC) which was prepare via Lipozyme RMIM mediated partial hydrolysis of EPA-PC, squid DHA bound diacyl phospholipid (DHA-PC), and DHA bound monoacyl phospholipid (DHA-LPC) which was also prepare via Lipozyme RMIM mediated partial hydrolysis of DHA-PC, were subjected to antiangiogenic activity assay by using a piece of rat main artery and a human umbilical cord vein endothelial cell. The lengths of micro vein generated from those tissues after incubation with the above four kinds of phospholipid molecular species were measured and compared. EPA-LPC and DHA-LPC showed strong antiangiogenic activity on the rat main artery tissue, while on the human umbilical cord vein endothelial cells, 100 μM of EPA-LPC in the culture medium, exhibited the most effective suppression on angiogenesis, followed by 100 μM of DHA-LPC. It was concluded that EPA-LPC obtained via Lipozyme RMIM mediated partial hydrolysis of EPA-PC is the most effective omega 3 phospholipid on anti-angiogenesis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
公益社団法人 日本油化学会 |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.5650/jos.61.427 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.5650/jos.61.427 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1345-8957 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1347-3352 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11503337 |
| 開始ページ |
|
|
開始ページ |
427 |
| 書誌情報 |
Journal of Oleo Science
Journal of Oleo Science
巻 61,
号 8,
p. 427-432,
発行日 2012
|
| 旧ID |
48188 |
JOleoSci_61_427.pdf (1.5 MB)
