| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Continuous monitoring of hypothalamic neurotransmitters and thermoregulatory responses in exercising rats |
|
言語 |
en |
| 作成者 |
Hasegawa, Hiroshi
Takatsu, Satomi
Ishiwata, Takayuki
Tanaka, Hideto
Sarre, Sophie
Meeusen, Romain
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
(c) 2011 Elsevier B.V. All rights reserved. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Microdialysis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Exercise |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Thermoregulation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Neurotransmission |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
460 |
| 内容記述 |
|
|
内容記述 |
The purpose of the present study was to investigate the relationship between thermoregulation and catecholamine release in the preoptic area and anterior hypothalamus (PO/AH) during incremental treadmill running in the rat. To this aim, we combined in vivo brain microdialysis, biotelemetry and metabolic measurements for continuous monitoring of core body temperature (T(core)), neurotransmitters and thermoregulatory responses. The animals were exercised for 1 h at 23 degrees C. Treadmill speed was increased every 20 min (10, 20 and 26 m min(-1)). T(core). oxygen consumption (VO(2), an index of heat production) and tail skin temperature (T(tail), an index of heat loss) were simultaneously measured. Brain microdialysis samples were collected every 10 min, and these samples were analyzed for noradrenaline (NA), dopamine (DA) and serotonin (5-HT). T(core) and VO(2) significantly increased during treadmill and were exercise intensity dependent. After an initial drop T(tail) increased significantly during exercise. Both NA and DA levels in the PO/AH increased significantly during exercise. There was no effect on serotonin release. T(core). VO(2) and T(tail) were positively correlated with the levels of NA and DA. Our data suggest that thermoregulatory responses are dependent on the intensity of the exercise and that these responses are associated with changes in NA and DA release, but not in 5-HT release in the PO/AH. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Science BV |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jneumeth.2011.05.024 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.jneumeth.2011.05.024 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0165-0270 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00703367 |
| 開始ページ |
|
|
開始ページ |
119 |
| 書誌情報 |
Journal of Neuroscience Methods
Journal of Neuroscience Methods
巻 202,
号 2,
p. 119-123,
発行日 2011
|
| 旧ID |
34823 |
JNeurosciMethod_202_119.pdf (333.6 KB)
