| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Host factors contributing to the discovery of gastric cancer after successful eradication therapy of Helicobacter pylori |
|
言語 |
en |
| 作成者 |
Takata, Shunsuke
Ito, Masanori
Yoshihara, Masaharu
Tanaka, Shinji
Imagawa, Shinobu
Haruma, Ken
Chayama, Kazuaki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2006 Authors ; Journal compilation (c) 2007 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
eradication |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
gastric cancer |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
gastrin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Helicobacter pylori |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
pepsinogen |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Background and Aim: Clinical features of patients who develop gastric cancer after successful eradication of Helicobacter pylori are still unclear. We attempted to identify host factors associated with the discovery of gastric cancer, including changes in the background gastric mucosa in patients with atrophic gastritis. Methods: We enrolled 101 patients (59 men, 42 women; mean age 56.0 years) who underwent successful eradication therapy. All patients had no neoplastic lesion in the stomach and were diagnosed with corpus atrophic gastritis histologically before the eradication therapy. After successful eradication, these patients were followed up by an annual endoscopic examination (mean follow-up time 63.2 months; range 12–157 months). Fasting sera were obtained before and after eradication therapy and the serum levels of gastrin/pepsinogens were evaluated. Results: Gastric cancer occurred during follow-up in eight of the 101 patients (7.9%). We compared the host features between the cancer-discovered group (n = 8) and the non-discovered group (n = 93). We found no difference in gender, history of previous treatment of gastric cancer, and serum pepsinogen/gastrin levels at entry between them. The trends in alterations of serum markers did not differ between the two groups. However, gastric cancer was more frequently found in older patients (>54 years at eradication) than in others (P < 0.05). Conclusion: Improvement of gastric inflammation did not correlate with the discovery of gastric cancer after eradication; however, age at the time of eradication seemed to be important. Strict follow-up after eradication is needed in older patients with atrophic gastritis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Blackwell |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/j.1440-1746.2006.04776.x |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1111/j.1440-1746.2006.04776.x |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10727383 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0815-9319 |
| 開始ページ |
|
|
開始ページ |
571 |
| 書誌情報 |
Journal of Gastroenterology and Hepatology
Journal of Gastroenterology and Hepatology
巻 22,
号 4,
p. 571-576,
発行日 2007-04
|
| 旧ID |
22758 |
JGH_22_571.pdf (246.0 KB)
