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Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradiation therapy

https://hiroshima.repo.nii.ac.jp/records/2007337
https://hiroshima.repo.nii.ac.jp/records/2007337
bd81a4ff-e5a0-4deb-a2f0-48f4bde515f8
名前 / ファイル ライセンス アクション
JGastroenterol_54_907.pdf JGastroenterol_54_907.pdf (5.7 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradiation therapy
言語 en
作成者 Masuda, Kazuhiko

× Masuda, Kazuhiko

en Masuda, Kazuhiko

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Urabe, Yuji

× Urabe, Yuji

en Urabe, Yuji

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Itou, Masanori

× Itou, Masanori

en Itou, Masanori

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Ono, Atsushi

× Ono, Atsushi

en Ono, Atsushi

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Nelson, Hayes Clair

× Nelson, Hayes Clair

en Nelson, Hayes Clair

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Nakamura, Koki

× Nakamura, Koki

en Nakamura, Koki

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Kotachi, Takahiro

× Kotachi, Takahiro

en Kotachi, Takahiro

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Boda, Tomoyuki

× Boda, Tomoyuki

en Boda, Tomoyuki

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Tanaka, Shinji

× Tanaka, Shinji

en Tanaka, Shinji

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Chayama, Kazuaki

× Chayama, Kazuaki

en Chayama, Kazuaki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © The Author(s) 2019
権利情報
権利情報 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
主題
主題Scheme Other
主題 Gastric cancer
主題
主題Scheme Other
主題 Eradiation therapy for Helicobacter pylori
主題
主題Scheme Other
主題 Epithelium with low-grade atypia
主題
主題Scheme Other
主題 Laser microdissection
内容記述
内容記述 Background Gastric cancer may develop after successful eradication of Helicobacter pylori, although the incidence is lower than in non-eradicated individuals. We previously reported the appearance of characteristic epithelium with low-grade atypia (ELA) on the surface of gastric cancer after H. pylori eradication. However, whether ELA originates from cancer after re-differentiation or from the non-cancerous surrounding mucosa is unknown. Methods We isolated ELA regions from 10 early gastric cancer patients and analyzed the nucleotide sequences for 90 oncogenes and 35 fusion oncogenes, comparing them with counterpart cancer tissue, normal gastric mucosa, and blood cell-derived DNA. Somatic mutations in each tissue were identified by comparing them with the sequences from whole blood-derived DNA. Result Gene alterations were observed in nine of the ten patients, and up to 42 and 70 somatic mutations were seen in cancer and ELA samples, respectively. Common mutations shared between cancer and ELA tissues were found in eight of these nine patients. In contrast, common mutations between non-cancer mucosa and ELA were only detected in one patient, who also had common mutation between cancer and ELA. ELA-specific nucleotide substitutions were seen in seven patients. In contrast, cancer-specific substitutions were only found in two patients. 18 out of 19 amino acid substitutions present in cancer tissue were also identified in ELA. These results suggest that ELA originated from cancer tissue and accumulated further nucleotide substitutions. Conclusions Differential diagnosis of ELA and normal mucosa should be carefully performed to prevent misdiagnosis of ELA as normal mucosa with atypia.
言語 en
内容記述
内容記述タイプ Other
内容記述 This study was supported by grants from the Japan Society for the Promotion of Science (JSPS KAKENHI GrantNumber: 16K19379; https://www.jsps.go.jp/j-grantsinaid/).
出版者
出版者 Springer Japan
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1007/s00535-019-01596-4
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00535-019-01596-4
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0944-1174
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1435-5922
開始ページ
開始ページ 907
書誌情報 Journal of Gastroenterology
Journal of Gastroenterology

巻 54, 号 10, p. 907-915, 発行日 2019-10
旧ID 48208
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