| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Tumor Induction by Azoxymethane (AOM) and 2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in F344 Rat Gastric Mucosa Featuring Intestinal Metaplasia Caused by X-irradiation |
|
言語 |
en |
| 作成者 |
Kashiwabara, Shoji
Kashimoto, Naoki
Uesaka, Toshihiro
Wakabayashi, Keiji
Kamiya, Kenji
Watanabe, Hiromitsu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2005 S. Kashiwabara et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Gastric tumor |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Azoxymethane |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
F344 rats |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Intestinal metaplasia |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Male F344 5-week-old rats were X-irradiated, and 16 weeks after the first dose. azoxymethane (AOM) was injected or 2-amino-l-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) was given by intragastric intubation. Tumors in the pylorus of the glandular stomach were observed in 4 out of the 29 animals receiving X-rays + AOM and in 4 out of the 25 animals receiving X-rays + PhIP, 12 months after administration. No such lesions were found in the chemical or X-ray alone groups. Intestinal metaplasia and some induced tumors were positive for CDX2. It was concluded that the presence of intestinal metaplasia may increase sensitivity to the induction of gastric tumors by colon carcinogens. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
BioMed Central |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0392-9078 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12034934 |
| 開始ページ |
|
|
開始ページ |
305 |
| 書誌情報 |
Journal of Experimental & Clinical Cancer Research
Journal of Experimental & Clinical Cancer Research
巻 24,
号 2,
p. 305-312,
発行日 2005
|
| 旧ID |
30817 |
JExpClinCancerRes_24_305.pdf (676.3 KB)
