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1α,25-dihydroxyvitamin D3 acts predominately in mature osteoblasts under conditions of high extracellular phosphate to increase fibroblast growth factor 23 production in vitro

https://hiroshima.repo.nii.ac.jp/records/2007328
https://hiroshima.repo.nii.ac.jp/records/2007328
7da613f1-30ba-4771-a55e-161ed75c4c4e
名前 / ファイル ライセンス アクション
JEndocrinol_206_279.pdf JEndocrinol_206_279.pdf (228.9 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル 1α,25-dihydroxyvitamin D3 acts predominately in mature osteoblasts under conditions of high extracellular phosphate to increase fibroblast growth factor 23 production in vitro
言語 en
作成者 Yamamoto, Ryoko

× Yamamoto, Ryoko

en Yamamoto, Ryoko

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Minamizaki, Tomoko

× Minamizaki, Tomoko

en Minamizaki, Tomoko

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Yoshiko, Yuji

× Yoshiko, Yuji

en Yoshiko, Yuji

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Yoshioka, Hirotaka

× Yoshioka, Hirotaka

en Yoshioka, Hirotaka

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Tanne, Kazuo

× Tanne, Kazuo

en Tanne, Kazuo

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Aubin, Jane E

× Aubin, Jane E

en Aubin, Jane E

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Maeda, Norihiko

× Maeda, Norihiko

en Maeda, Norihiko

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © 2010 Society for Endocrinology. This is an Open Access article distributed under the terms of the Society for Endocrinology’s Re-use Licence which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
内容記述
内容記述 Osteoblasts/osteocytes are the principle sources of fibroblast growth factor 23 (FGF23), a phosphaturic hormone, but the regulation of FGF23 expression during osteoblast development remains uncertain. Because 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and inorganic phosphate (Pi) may act as potent activators of FGF23 expression, we estimated how these molecules regulate FGF23 expression during rat osteoblast development in vitro. 1,25(OH)2D3-dependent FGF23 production was restricted largely to mature cells in correlation with increased vitamin D receptor (VDR) mRNA levels, in particular, when Pi was present. Pi alone and more so in combination with 1,25(OH)2D3 increased FGF23 production and VDR mRNA expression. Parathyroid hormone, stanniocalcin 1, prostaglandin E2, FGF2, and foscarnet did not increase FGF23 mRNA expression. Thus, these results suggest that 1,25(OH)2D3 may exert its largest effect on FGF23 expression/production when exposed to high levels of extracellular Pi in osteoblasts/osteocytes.
言語 en
内容記述
内容記述タイプ Other
内容記述 This work was supported in part by grants from the Ministry of Education, Science, Sports and Culture of Japan (18592001 to YY) and the Canadian Institutes of Health Research (FRN 83704 to JEA).
出版者
出版者 Society for Endocrinology
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1677/JOE-10-0058
関連情報
識別子タイプ PMID
関連識別子 20530653
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1677/JOE-10-0058
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0022-0795
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1479-6805
開始ページ
開始ページ 279
書誌情報 Journal of Endocrinology
Journal of Endocrinology

巻 206, 号 3, p. 279-286, 発行日 2010-09
旧ID 48984
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