| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Neodymium-doped Yttrium-Aluminium-Garnet Laser Irradiation Abolishes the Increase in Interleukin-6 Levels Caused by Peptidoglycan through the p38 Mitogen-activated Protein Kinase Pathway in Human Pulp Cells |
|
言語 |
en |
| 作成者 |
Shiba, Hideki
Tsuda, Hidehiro
Kajiya, Mikihito
Fujita, Tsuyoshi
Takeda, Katsuhiro
Hino, Takamune
Kawaguchi, Hiroyuki
Kurihara, Hidemi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 American Association of Endodontists Published by Elsevier Inc. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Human pulp cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
interleukin-6 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
mitogen-activated protein kinases |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
neodymium-doped yttrium-aluminium-garnet laser |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The anti-inflammatory effects of low-power laser irradiation have previously been reported. However, how the laser irradiation regulates the expression of inflammatory cytokines remains unknown. In the present study, to elucidate the mechanism behind the anti-inflammatory effect, we examined the effects of low-power neodymium-doped yttrium-aluminium-garnet (Nd:YAG) laser irradiation on interleukin (IL)-6 expression in human pulp (HP) cells stimulated by peptidoglycan (PGN) and focused on intracellular signaling pathways. Low-power Nd:YAG laser irradiation obviated the PGN-induced increase in IL-6 levels in HP cells. A p38 mitogen-activated protein kinase inhibitor, SB203580, also inhibited the increase in IL-6 messenger RNA levels. PGN stimulated the activity of phosphorylated p38 in HP cells. Low-power laser irradiation inhibited the activity. Thus, suppression of the phosphorylated p38 activity by low-power laser irradiation in HP cells culminates in inhibition of the increase in IL-6 induced by PGN, suggesting that low-power laser irradiation regulates intracellular signaling molecule activities to exert its anti-inflammatory effect. (J Endod 2009;35:373-376) |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Science INC |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.joen.2008.11.028 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.joen.2008.11.028 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0099-2399 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10614412 |
| 開始ページ |
|
|
開始ページ |
373 |
| 書誌情報 |
Journal of Eenodontics
Journal of Eenodontics
巻 35,
号 3,
p. 373-376,
発行日 2009
|
| 旧ID |
27714 |
JEndodon_35_373.pdf (347.0 KB)
