| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Optical biopsy of early gastroesophageal cancer by catheter-based reflectance-type laser-scanning confocal microscopy |
|
言語 |
en |
| 作成者 |
Nakao, Madoka
Yoshida, Shigeto
Tanaka, Shinji
Takemura, Yoshito
Oka, Shiro
Yoshihara, Masaharu
Chayama, Kazuaki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2008 Society of Photo-Optical Instrumentation Engineers |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Magnified endoscopic observation of the gastrointestinal tract has become possible. However, such observation at the cellular level remains difficult. Laser-scanning confocal microscopy (LCM) is a novel, noninvasive optical imaging method that provides instant microscopic images of untreated tissue under endoscopy. We compared prototype catheter-based reflectance-type LCM images in vivo and histologic images of early gastroesophageal cancer to assess the usefulness of LCM in diagnosing such cancer. Twenty sites in the esophagus and 40 sites in the stomach were examined by LCM under endoscopy prior to endoscopic or surgical resection. A prototype catheter LCM system, equipped with a semiconductor laser that oscillates at 685 nm and analyzes reflected light (Mauna Kea Technologies, Paris, France; Fujinon, Saitama, Japan), was used in vivo without fluorescent agent. In all normal esophageal mucosa and esophageal cancers, the nuclei were visualized. In 9 of the 10 normal esophageal mucosa, cell membranes were visualized, and in 5 of the 10 esophageal cancers, cell membranes were visualized. In all normal gastric mucosa, nuclei and cell membranes were not visualized, but in 10 of the 20 gastric cancers, nuclei were visualized. This novel method will aid in immediate diagnosis under endoscopy without the need for biopsy. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
SPIE |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1117/1.2983674 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1117/1.2983674 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1083-3668 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11237889 |
| 開始ページ |
|
|
開始ページ |
54043 |
| 書誌情報 |
Journal of Biomedical Optics
Journal of Biomedical Optics
巻 13,
号 5,
p. 54043,
発行日 2008
|
| 旧ID |
25931 |
JBiomedOpt_13_54043.pdf (1.7 MB)
