| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2024-12-16 |
| タイトル |
|
|
タイトル |
Differences in postoperative prognosis between early-stage lung adenocarcinoma and squamous cell carcinoma |
|
言語 |
en |
| 作成者 |
Yu Izaki
Mimae, Takahiro
Kagimoto, Atsushi
Handa, Yoshinori
Tsutani, Yasuhiro
Miyata, Yoshihiro
Okada, Morihito
Takeshima, Yukio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is a pre-copyedited, author-produced version of an article accepted for publication in Japanese Journal of Clinical Oncology following peer review. The version of record Volume 54, Issue 7, July 2024, Pages 813–821 is available online at: https://doi.org/10.1093/jjco/hyae049. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
surgery |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prognosis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lung cancer |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
adenocarcinoma |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
squamous cell carcinoma |
| 内容記述 |
|
|
内容記述 |
Background Although prognosis and treatments differ between small-cell- and nonsmall-cell carcinoma, comparisons of the histological types of NSCLC are uncommon. Thus, we investigated the oncological factors associated with the prognosis of early-stage adenocarcinoma and squamous cell carcinoma. Methods We retrospectively compared the clinicopathological backgrounds and postoperative outcomes of patients diagnosed with pathological stage I–IIA adenocarcinoma and squamous cell carcinoma primary lung cancer completely resected at our department from January 2007 to December 2017. Multivariable Cox regression analysis for overall survival and recurrence-free survival was performed. Results The median follow-up duration was 55.2 months. The cohort consisted of 532 adenocarcinoma and 96 squamous cell carcinoma patients. A significant difference in survival was observed between the two groups, with a 5-year overall survival rate of 90% (95% confidence interval 86–92%) for adenocarcinoma and 77% (95% CI 66–85%) for squamous cell carcinoma (P < 0.01) patients. Squamous cell carcinoma patients had worse outcomes compared to adenocarcinoma patients in stage IA disease, but there were no significant differences between the two groups in stage IB or IIA disease. In multivariate analysis, invasion diameter was associated with overall survival in adenocarcinoma (hazard ratio 1.76, 95% confidence interval 1.36–2.28), but there was no such association in squamous cell carcinoma (hazard ratio 0.73, 95% confidence interval 0.45–1.14). Conclusions The importance of tumor invasion diameter in postoperative outcomes was different between adenocarcinoma and squamous cell carcinoma. Thus, it is important to consider that nonsmall-cell carcinoma may have different prognoses depending on the histological type, even for the same stage. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Oxford |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1093/jjco/hyae049 |
| 開始ページ |
|
|
開始ページ |
813 |
| 書誌情報 |
en : Japanese Journal of Clinical Oncology
巻 54,
号 7,
p. 813-821,
発行日 2024-04-27
|
| 旧ID |
55859 |
| 備考 |
エンバーゴ済、6months |
JJCO_54_813.pdf (1.7 MB)
