| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls |
|
言語 |
en |
| 作成者 |
Ishikawa, Nobuhisa
Hattori, Noboru
Kohno, Nobuoki
Kobayashi, Akihiro
Hayamizu, Tomoyuki
Johnson, Malcolm
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
© 2015 Ishikawa et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
chronic obstructive pulmonary disease |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
inflammatory cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
biomarkers |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
sputum |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
serum |
| 内容記述 |
|
|
内容記述 |
Purpose: To assess the importance of inflammation in chronic obstructive pulmonary disease (COPD) by measuring airway and systemic inflammatory biomarkers in Japanese patients with the disease and relevant control groups. Patients and methods: This was the first study of its type in Japanese COPD patients. It was a non-treatment study in which 100 participants were enrolled into one of three groups: nonsmoking controls, current or ex-smoking controls, and COPD patients. All participants underwent standard lung function assessments and provided sputum and blood samples from which the numbers of inflammatory cells and concentrations of biomarkers were measured, using standard procedures. Results: The overall trends observed in levels of inflammatory cells and biomarkers in sputum and blood in COPD were consistent with previous reports in Western studies. Increasing levels of neutrophils, interleukin 8 (IL-8), surfactant protein D (SP-D), and Krebs von den Lungen 6 (KL-6) in sputum and clara cell 16 (CC-16), high-sensitivity C-reactive protein (hs-CRP), and KL-6 in serum and plasma fibrinogen were seen in the Japanese COPD patients compared with the non-COPD control participants. In sputum, significant correlations were seen between total cell count and matrix metalloproteinase 9 (MMP-9; P＜0.001), neutrophils and MMP-9 (P＜0.001), macrophages and KL-6 (P＜0.01), total cell count and IL-8 (P＜0.05), neutrophils and IL-8 (P＜0.05), and macrophages and MMP-9 (P＜0.05). Significant correlations were also observed between some inflammatory cells in sputum and biomarkers in serum, with the most significant between serum CC-16 and both total cell count (P＜0.005) and neutrophils (P＜0.005) in sputum. Conclusion: These results provide evidence for the first time that COPD in Japanese patients is a multicomponent disease, involving both airway and systemic inflammation, in addition to airway obstruction. Therefore, intervention with anti-inflammatory therapy may provide additional benefit in disease management of COPD in Japan. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dove Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.2147/COPD.S74557 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2147/COPD.S74557 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1178-2005 |
| 開始ページ |
|
|
開始ページ |
185 |
| 書誌情報 |
International Journal of COPD
International Journal of COPD
巻 10,
号 1,
p. 185-192,
発行日 2015-01-23
|
| 旧ID |
48658 |
InterJCOPD_10_185.pdf (385.2 KB)
