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Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls

https://hiroshima.repo.nii.ac.jp/records/2007085
https://hiroshima.repo.nii.ac.jp/records/2007085
7eda5fdc-b945-43ba-b0ad-bfd49e421c27
名前 / ファイル ライセンス アクション
InterJCOPD_10_185.pdf InterJCOPD_10_185.pdf (385.2 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls
言語 en
作成者 Ishikawa, Nobuhisa

× Ishikawa, Nobuhisa

en Ishikawa, Nobuhisa

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Hattori, Noboru

× Hattori, Noboru

en Hattori, Noboru

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Kohno, Nobuoki

× Kohno, Nobuoki

en Kohno, Nobuoki

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Kobayashi, Akihiro

× Kobayashi, Akihiro

en Kobayashi, Akihiro

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Hayamizu, Tomoyuki

× Hayamizu, Tomoyuki

en Hayamizu, Tomoyuki

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Johnson, Malcolm

× Johnson, Malcolm

en Johnson, Malcolm

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © 2015 Ishikawa et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
主題
主題Scheme Other
主題 chronic obstructive pulmonary disease
主題
主題Scheme Other
主題 inflammatory cells
主題
主題Scheme Other
主題 biomarkers
主題
主題Scheme Other
主題 sputum
主題
主題Scheme Other
主題 serum
内容記述
内容記述 Purpose: To assess the importance of inflammation in chronic obstructive pulmonary disease (COPD) by measuring airway and systemic inflammatory biomarkers in Japanese patients with the disease and relevant control groups. Patients and methods: This was the first study of its type in Japanese COPD patients. It was a non-treatment study in which 100 participants were enrolled into one of three groups: nonsmoking controls, current or ex-smoking controls, and COPD patients. All participants underwent standard lung function assessments and provided sputum and blood samples from which the numbers of inflammatory cells and concentrations of biomarkers were measured, using standard procedures. Results: The overall trends observed in levels of inflammatory cells and biomarkers in sputum and blood in COPD were consistent with previous reports in Western studies. Increasing levels of neutrophils, interleukin 8 (IL-8), surfactant protein D (SP-D), and Krebs von den Lungen 6 (KL-6) in sputum and clara cell 16 (CC-16), high-sensitivity C-reactive protein (hs-CRP), and KL-6 in serum and plasma fibrinogen were seen in the Japanese COPD patients compared with the non-COPD control participants. In sputum, significant correlations were seen between total cell count and matrix metalloproteinase 9 (MMP-9; P<0.001), neutrophils and MMP-9 (P<0.001), macrophages and KL-6 (P<0.01), total cell count and IL-8 (P<0.05), neutrophils and IL-8 (P<0.05), and macrophages and MMP-9 (P<0.05). Significant correlations were also observed between some inflammatory cells in sputum and biomarkers in serum, with the most significant between serum CC-16 and both total cell count (P<0.005) and neutrophils (P<0.005) in sputum. Conclusion: These results provide evidence for the first time that COPD in Japanese patients is a multicomponent disease, involving both airway and systemic inflammation, in addition to airway obstruction. Therefore, intervention with anti-inflammatory therapy may provide additional benefit in disease management of COPD in Japan.
言語 en
出版者
出版者 Dove Press
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.2147/COPD.S74557
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.2147/COPD.S74557
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1178-2005
開始ページ
開始ページ 185
書誌情報 International Journal of COPD
International Journal of COPD

巻 10, 号 1, p. 185-192, 発行日 2015-01-23
旧ID 48658
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