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Is Self-Rated Health Associated with Blood Immune Markers in Healthy Individuals?

https://hiroshima.repo.nii.ac.jp/records/2007084
https://hiroshima.repo.nii.ac.jp/records/2007084
b8e996b5-fca3-4d2d-b7e2-cf0d81024b3e
名前 / ファイル ライセンス アクション
IntJBehavMed_17_234.pdf IntJBehavMed_17_234.pdf (236.8 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Is Self-Rated Health Associated with Blood Immune Markers in Healthy Individuals?
言語 en
作成者 Nakata, Akinori

× Nakata, Akinori

en Nakata, Akinori

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Takahashi, Masaya

× Takahashi, Masaya

en Takahashi, Masaya

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Otsuka, Yasumasa

× Otsuka, Yasumasa

en Otsuka, Yasumasa

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Swanson, Naomi G.

× Swanson, Naomi G.

en Swanson, Naomi G.

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2010 Springer
主題
主題Scheme Other
主題 self-rated health
主題
主題Scheme Other
主題 immune system
主題
主題Scheme Other
主題 B cell
主題
主題Scheme Other
主題 IgG
主題
主題Scheme Other
主題 cytokine
主題
主題Scheme Other
主題 psychoimmunology
主題
主題Scheme NDC
主題 140
内容記述
内容記述 Background: Although self-rated health (SRH) has been established as a robust predictor of morbidity and mortality, the immunological mechanisms underpinning this relationship are poorly understood. Purpose: This study examined the association of SRH with humoral and cellular immune markers in healthy individuals who reported no physical illnesses. Method: A total of 116 healthy Japanese white-collar employees (79 women and 37 men) at a pharmaceutical company, aged 23-62 (mean 32) years, underwent a blood draw for the measurement of circulating immune (T, B, and natural killer (NK)) cells, inflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-α (TNF- α)), and plasma immunoglobulin G (IgG) and completed a health survey including SRH. The question regarding SRH ranged from 'very good (coded 1)' to 'very poor (coded 5).' Hierarchical multiple regression analysis was carried out to calculate the relationship between SRH and immune markers. Results: In this sample, poor SRH was positively correlated with B (CD19+) cell numbers (β=.260, p<.05) and IgG levels (β=.335, p<.01), even after adjusting for depressive symptoms, age, education, marital status, smoking, alcohol consumption, physical activity, body mass index, sex, and sex × SRH interaction. The interaction between SRH and sex on the immune markers was not significant. Conclusion: Although the connection between SRH and immune markers was not strong in this context, the results suggest that poor SRH may be associated with reduced humoral immune system capacity to respond to new/latent challenges. The results provide some support for the immunological basis of SRH in healthier individuals.
言語 en
出版者
出版者 Springer Boston
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
関連情報
関連名称 The original publication is available at www.springerlink.com
関連情報
識別子タイプ DOI
関連識別子 10.1007/s12529-010-9102-0
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1007/s12529-010-9102-0
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1070-5503
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA11043408
開始ページ
開始ページ 234
書誌情報 International Journal of Behavioral Medicine
International Journal of Behavioral Medicine

巻 17, 号 3, p. 234-242, 発行日 2010
旧ID 30409
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