| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Is Self-Rated Health Associated with Blood Immune Markers in Healthy Individuals? |
|
言語 |
en |
| 作成者 |
Nakata, Akinori
Takahashi, Masaya
Otsuka, Yasumasa
Swanson, Naomi G.
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright (c) 2010 Springer |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
self-rated health |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
immune system |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
B cell |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
IgG |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cytokine |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
psychoimmunology |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
140 |
| 内容記述 |
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|
内容記述 |
Background: Although self-rated health (SRH) has been established as a robust predictor of morbidity and mortality, the immunological mechanisms underpinning this relationship are poorly understood. Purpose: This study examined the association of SRH with humoral and cellular immune markers in healthy individuals who reported no physical illnesses. Method: A total of 116 healthy Japanese white-collar employees (79 women and 37 men) at a pharmaceutical company, aged 23-62 (mean 32) years, underwent a blood draw for the measurement of circulating immune (T, B, and natural killer (NK)) cells, inflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-α (TNF- α)), and plasma immunoglobulin G (IgG) and completed a health survey including SRH. The question regarding SRH ranged from 'very good (coded 1)' to 'very poor (coded 5).' Hierarchical multiple regression analysis was carried out to calculate the relationship between SRH and immune markers. Results: In this sample, poor SRH was positively correlated with B (CD19+) cell numbers (β=.260, p<.05) and IgG levels (β=.335, p<.01), even after adjusting for depressive symptoms, age, education, marital status, smoking, alcohol consumption, physical activity, body mass index, sex, and sex × SRH interaction. The interaction between SRH and sex on the immune markers was not significant. Conclusion: Although the connection between SRH and immune markers was not strong in this context, the results suggest that poor SRH may be associated with reduced humoral immune system capacity to respond to new/latent challenges. The results provide some support for the immunological basis of SRH in healthier individuals. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer Boston |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
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|
関連名称 |
The original publication is available at www.springerlink.com |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s12529-010-9102-0 |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1007/s12529-010-9102-0 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1070-5503 |
| 収録物識別子 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11043408 |
| 開始ページ |
|
|
開始ページ |
234 |
| 書誌情報 |
International Journal of Behavioral Medicine
International Journal of Behavioral Medicine
巻 17,
号 3,
p. 234-242,
発行日 2010
|
| 旧ID |
30409 |
IntJBehavMed_17_234.pdf (236.8 KB)
