| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring |
|
言語 |
en |
| 作成者 |
Kurata, Akiko
Morinobu, Shigeru
Fuchikami, Manabu
Yamamoto, Shigeto
Yamawaki, Shigeto
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 Elsevier Inc. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Learned helplessness |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Early postpartum period |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Maternal behavior |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Hypothalamic-pituitary-adrenal (HPA) axis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Glucocorticoid receptor |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Corticosterone |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
It is known that the early environment affects the mental development of rodent and human offspring. However, it is not known specifically whether a postpartum depressive state influences the depressive state in offspring. Using learned helplessness (LH) in rats as an animal model of depression, we examined the influence of maternal postpartum LH on responses to the LH test of offspring. Dam rats were judged as LH or non-helpless (nLH) on postnatal days (PN) 2-3, and maternal behavior was recorded during PN2-14. On PN 45-46, offspring were subjected to the LH test. Plasma corticosterone (CORT) levels, hippocampal levels of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) mRNA were measured before and after the LH test in offspring. Active nursing in LH dams was significantly lower than that in nLH dams. Susceptibility to LH in the offspring of LH dams was significantly higher than in those of nLH dams, and was negatively correlated with active nursing by LH dams. The GR mRNA levels before and after the LH test were lower in the offspring of LH dams than in those of nLH dams, and the reduced basal GR mRNA and protein might have resulted in the higher CORT response after the LH test. There was no significant difference in BDNF mRNA in the offspring of LH and nLH dams. These findings suggest that early postpartum LH decreased active nursing and increased depression-like behavior in the adolescent offspring via dysfunction of the hypothalamic-pituitary-ad renal axis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Academic Press Inc |
| 出版者 |
|
|
出版者 |
Elsevier Science |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.yhbeh.2009.03.016 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.yhbeh.2009.03.016 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-506X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00665370 |
| 開始ページ |
|
|
開始ページ |
112 |
| 書誌情報 |
Hormones and Behavior
Hormones and Behavior
巻 56,
号 1,
p. 112-120,
発行日 2009
|
| 旧ID |
27761 |
HormBeh_56_112.pdf (510.2 KB)
