| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Deficiency of the basic helix‐loop‐helix transcription factor DEC1 prevents obesity induced by a high‐fat diet in mice |
|
言語 |
en |
| 作成者 |
Noshiro, Mitsuhide
Kawamoto, Takeshi
Nakashima, Ayumu
Ozaki, Noritsugu
Ueno, Toshinori
Saeki, Masayumi
Honda, Kiyomasa
Fujimoto, Katsumi
Kato, Yukio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
This is the peer reviewed version of the following article: Noshiro, M, Kawamoto, T, Nakashima, A, et al. Deficiency of the basic helix‐loop‐helix transcription factor DEC1 prevents obesity induced by a high‐fat diet in mice. Genes Cells. 2018; 23: 658– 669, which has been published in final form at https://doi.org/10.1111/gtc.12607. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| 権利情報 |
|
|
権利情報 |
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
circadian rhythms |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
DEC1 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
energy homeostasis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
lipid metabolism |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
obesity |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
PPAR |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
PPRE |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
RXR |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
thermogenesis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
UCP1 |
| 内容記述 |
|
|
内容記述 |
Obesity is a major public health problem in developed countries resulting from increased food intake and decreased energy consumption and usually associated with abnormal lipid metabolism. Here, we show that DEC1, a basic helix‐loop‐helix transcription factor, plays an important role in the regulation of lipid consumption in mouse brown adipose tissue (BAT), which is the major site of thermogenesis. Homozygous Dec1 deletion attenuated high‐fat‐diet‐induced obesity, adipocyte hypertrophy, fat volume and hepatic steatosis. Furthermore, DEC1 deficiency increased body temperature during daytime and enhanced the expression of uncoupler protein 1, a key factor of thermogenesis, and various lipolysis‐related genes in interscapular BAT. In vitro experiments suggested that DEC1 suppresses the expression of various lipolysis‐related genes induced by the heterodimer of peroxisome proliferator‐activated receptor γ and retinoid X receptor α (RXRα) through direct binding to RXRα. These observations suggest that enhanced lipolysis in BAT caused by DEC1 deficiency leads to an increase in lipid consumption, thereby decreasing lipid accumulation in adipose tissues and the liver. Thus, DEC1 may serve as an energy‐saving factor that suppresses lipid consumption, which may be relevant to managing obesity. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by Grants‐in‐Aid for Science from the Japan Society for the Promotion of Science (grant numbers 22590223 and 2339042351). |
| 出版者 |
|
|
出版者 |
Molecular Biology Society of Japan |
| 出版者 |
|
|
出版者 |
Wiley |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/gtc.12607 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
29968353 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/gtc.12607 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1356-9597 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1365-2443 |
| 開始ページ |
|
|
開始ページ |
658 |
| 書誌情報 |
Genes to Cells
Genes to Cells
巻 23,
号 8,
p. 658-669,
発行日 2018-08-16
|
| 旧ID |
50466 |
GenesCells_23_658.pdf (1.4 MB)
