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Human cranial bone-derived mesenchymal stem cells cultured under simulated microgravity can improve cerebral infarction in rats

https://hiroshima.repo.nii.ac.jp/records/2006873
https://hiroshima.repo.nii.ac.jp/records/2006873
48e9c875-14c6-493a-925c-57199771b3b1
名前 / ファイル ライセンス アクション
ExpNeu_382_114947.pdf ExpNeu_382_114947.pdf (4.0 MB)
 Download is available from 2025/9/10.
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2025-01-17
タイトル
タイトル Human cranial bone-derived mesenchymal stem cells cultured under simulated microgravity can improve cerebral infarction in rats
言語 en
作成者 Kuwabara, Masashi

× Kuwabara, Masashi

en Kuwabara, Masashi

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Mitsuhara, Takafumi

× Mitsuhara, Takafumi

en Mitsuhara, Takafumi

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Teranishi, Masataka

× Teranishi, Masataka

en Teranishi, Masataka

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Okazaki, Takahito

× Okazaki, Takahito

en Okazaki, Takahito

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Takeda, Masaaki

× Takeda, Masaaki

en Takeda, Masaaki

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Ishii, Daizo

× Ishii, Daizo

en Ishii, Daizo

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Kondo, Hiroshi

× Kondo, Hiroshi

en Kondo, Hiroshi

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Shimizu, Kiyoharu

× Shimizu, Kiyoharu

en Shimizu, Kiyoharu

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Hosogai, Masahiro

× Hosogai, Masahiro

en Hosogai, Masahiro

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Hara, Takeshi

× Hara, Takeshi

en Hara, Takeshi

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Maeda, Yuyo

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en Maeda, Yuyo

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Kurose, Tomoyuki

× Kurose, Tomoyuki

en Kurose, Tomoyuki

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Kawahara, Yumi

× Kawahara, Yumi

en Kawahara, Yumi

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Yuge, Louis

× Yuge, Louis

en Yuge, Louis

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Horie, Nobutaka

× Horie, Nobutaka

en Horie, Nobutaka

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アクセス権
アクセス権 embargoed access
アクセス権URI http://purl.org/coar/access_right/c_f1cf
権利情報
言語 en
権利情報 © 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報
言語 en
権利情報 This is not the published version. Please cite only the published version.
権利情報
言語 ja
権利情報 この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
主題
言語 en
主題Scheme Other
主題 Mesenchymal stem cells
主題
言語 en
主題Scheme Other
主題 Simulated microgravity
主題
言語 en
主題Scheme Other
主題 Cerebral infarction
主題
言語 en
主題Scheme Other
主題 Human cranial bone
内容記述
内容記述 The efficacy of transplanting human cranial bone-derived mesenchymal stem cells (hcMSCs) cultured under simulated microgravity (sMG) conditions has been previously reported; however, their effect on cerebral infarction remains unknown. Here, we examined the efficacy of transplanting hcMSCs cultured in an sMG environment into rat models of cerebral infarction. For evaluating neurological function, hcMSCs cultured in either a normal gravity (1G) or an sMG environment were transplanted in rats 1 day after inducing cerebral infarction. The expression of endogenous neurotrophic, axonal, neuronal, synaptogenic, angiogenic, and apoptosis-related factors in infarcted rat brain tissue was examined using real-time polymerase chain reaction and western blotting 35 days after stroke induction. The RNAs of hcMSCs cultured under 1G or sMG environments were sequenced. The results showed that neurological function was significantly improved after transplantation of hcMSCs from the sMG group compared with that from the 1G group. mRNA expressions of nerve growth factor, fibroblast growth factor 2, and synaptophysin were significantly higher in the sMG group than in the 1G group, whereas sortilin 1 expression was significantly lower. RNA sequencing analysis revealed that genes related to cell proliferation, angiogenesis, neurotrophy, neural and synaptic organization, and inhibition of cell differentiation were significantly upregulated in the sMG group. In contrast, genes promoting microtubule and extracellular matrix formation and cell adhesion, signaling, and differentiation were downregulated. These results demonstrate that hcMSCs cultured in the sMG environment may be a useful source of stem cells for the recovery of neurological function after cerebral infarction.
言語 en
出版者
出版者 Elsevier
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.expneurol.2024.114947
助成情報
助成機関名 日本学術振興会
言語 ja
研究課題番号URI https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20K09348/
研究課題番号 20K09348
研究課題名 模擬微小重力環境で培養したヒト頭蓋骨由来間葉系幹細胞の脳梗塞ラットへの移植効果
言語 ja
助成情報
助成機関名 Japan Society for the Promotion of Science
言語 en
研究課題名 Effects of transplantation of human cranial bone-derived mesenchymal stem cells cultured in a simulated microgravity on rat cerebral infarction model
開始ページ
開始ページ 114947
書誌情報 en : Experimental Neurology

巻 382, p. 114947, 発行日 2024-09-10
旧ID 56125
備考 The full-text file will be made open to the public on 10 September 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'
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