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Differential activation of astrocytes and microglia after spinal cord injury in the fetal rat

https://hiroshima.repo.nii.ac.jp/records/2006862
https://hiroshima.repo.nii.ac.jp/records/2006862
66987ee0-230c-42a7-92af-d98beba3414b
名前 / ファイル ライセンス アクション
ESJ_15_223.pdf ESJ_15_223.pdf (2.5 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Differential activation of astrocytes and microglia after spinal cord injury in the fetal rat
言語 en
作成者 Fujimoto, Yoshinori

× Fujimoto, Yoshinori

en Fujimoto, Yoshinori

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Yamasaki, Takeshi

× Yamasaki, Takeshi

en Yamasaki, Takeshi

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Tanaka, Nobuhiro

× Tanaka, Nobuhiro

en Tanaka, Nobuhiro

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Mochizuki, Yu

× Mochizuki, Yu

en Mochizuki, Yu

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Kajihara, Hiroki

× Kajihara, Hiroki

en Kajihara, Hiroki

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Ikuta, Yoshikazu

× Ikuta, Yoshikazu

en Ikuta, Yoshikazu

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Ochi, Mitsuo

× Ochi, Mitsuo

en Ochi, Mitsuo

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2006 Springer-Verlag. "The original publication is available at www.springerlin.com"
主題
主題Scheme Other
主題 Fetal Surgery
主題
主題Scheme Other
主題 Immunohistochemistry
主題
主題Scheme Other
主題 Astrocytes
主題
主題Scheme Other
主題 Microglia
主題
主題Scheme Other
主題 Spinal cord injury
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Background: Because the immature spinal cord was nerve growth permissive, we examined glial reactions that influence regeneration of the spinal cord in a fetal rat spinal cord injury model. Methods: Three, 7, 21, and 35 days after intrauterine surgery, offsprings were killed and the thoracic and lumbar spinal cords were carefully removed from the spinal column and then cut into 10 m longitudinal sections. These sections were stained with hematoxylin-eosin, anti-glial fibrillary acidic protein antibody (GFAP) as a marker of astrocytes, and anti-complement CR3 antibody (OX-42) as a marker of microglia. A cordotomy model in young adult rat was utilized as a control. Results: In the present study, collagen fibers and scar formation were seen in the severed spinal cords of mature rats, but scar formation was not seen in the fetal rat cordotomy group, regardless of spinal continuity. In the Control group, biological activity of GFAP-positive cells increased over time. In the fetal rat cordotomy model, activity elevated slightly immediately after cordotomy, and disappeared shortly thereafter. In the Control group, OX-42 positive macrophage-like cells proliferated over time. However, in the fetal rat cordotomy model, OX-42 positive macrophage-like cells were recognized on postoperative days 3 and 7, and then disappeared. At 5 mm from the cordotomy site, reactive microglia were recognized in the white matter of Control group spinal cords, but these microglia were not recognized in the fetal rat cordotomy model. Conclusions: In the present study, collagen fibers and scar formation were seen in the severed spinal cords of adult rats, but scar formation was not seen in the fetal rat cordotomy group. Lack of inflammation and scar formation thus appear advantageous for regeneration of the fetal spinal cord. Between fetal and mature rats, chronological changes in the immunohistochemical reactions of astrocytes and microglia following cordotomy were compared, and the results confirmed many differences. The results of the prese
言語 en
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
関連情報
識別子タイプ DOI
関連識別子 10.1007/s00586-005-0933-3
関連情報
識別子タイプ PMID
関連識別子 16292632
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1007/s00586-005-0933-3
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0940-6719
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA10852035
開始ページ
開始ページ 223
書誌情報 European Spine Journal
European Spine Journal

巻 15, 号 2, p. 223-233, 発行日 2006-02-02
旧ID 17069
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