| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Glioblastoma treated with postoperative radio-chemotherapy : Prognostic value of apparent diffusion coefficient at MR imaging |
|
言語 |
en |
| 作成者 |
Yamasaki, Fumiyuki
Sugiyama, Kazuhiko
Ohtaki, Megu
Takeshima, Yukio
Abe, Nobukazu
Akiyama, Yuuji
Takaba, Junko
Vishwa, Jeet Amatya
Saitou, Taiichi
Kajiwara, Yoshinori
Hanaya, Ryosuke
Kurisu, Kaoru
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 Elsevier Ireland Ltd |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Apparent diffusion coefficient |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Echo planar imaging |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Glioblastoma |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Magnetic resonance imaging |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Overall survival |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Purpose: To retrospectively evaluate whether the mean, minimum, and maximum apparent diffusion coefficient (ADC) of glioblastomas obtained from pretreatment MR images is of prognostic value in patients with glioblastoma. Materials and methods: The institutional review board approved our study and waived the requirement for informed patient consent. Between February 1998 and January 2006, 33 patients (24 males, 9 females; age range 10–76 years) with supratentorial glioblastoma underwent pretreatment magnetic resonance (MR) imaging. The values of the mean, minimum, and maximum ADC (ADCmean, ADCMIN, and ADCMAX, respectively) of each tumor were preoperatively determined from several regions of interest defined in the tumors. After surgical intervention, all patients underwent irradiation and chemotherapy performed according to our hospital protocol. The patient age, symptom duration, Karnofsky performance scale score, extent of surgery, and ADC were assessed using factor analysis of overall survival. Prognostic factors were evaluated using Kaplan–Meier survival curves, the log-rank test, and multiple regression analysis with the Cox proportional hazards model. Results: Likelihood ratio tests confirmed that ADCMIN was the strongest among the three prognostic factors. Total surgical removal was the most important predictive factor for overall survival (P < 0.01). ADCMIN was also statistically correlated with overall survival (P < 0.05) and could be used to classify patients into different prognostic groups. Interestingly, ADCMIN was also the strongest prognostic factor (P < 0.01) in the group of patients in whom total tumor removal was not possible. Conclusion: The ADCMIN value obtained from pretreatment MR images is a useful clinical prognostic biomarker in patients with glioblastoma. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Ireland LTD |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.ejrad.2009.01.013 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.ejrad.2009.01.013 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0720-048X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10619405 |
| 開始ページ |
|
|
開始ページ |
532 |
| 書誌情報 |
European Journal of Radiology
European Journal of Radiology
巻 73,
号 3,
p. 532-537,
発行日 2010-03
|
| 旧ID |
30408 |
EurJRadiol_73_532.pdf (2.2 MB)
