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Glioblastoma treated with postoperative radio-chemotherapy : Prognostic value of apparent diffusion coefficient at MR imaging

https://hiroshima.repo.nii.ac.jp/records/2006855
https://hiroshima.repo.nii.ac.jp/records/2006855
8e541318-e3cc-4bae-a4b0-c9ebd65c3ad2
名前 / ファイル ライセンス アクション
EurJRadiol_73_532.pdf EurJRadiol_73_532.pdf (2.2 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Glioblastoma treated with postoperative radio-chemotherapy : Prognostic value of apparent diffusion coefficient at MR imaging
言語 en
作成者 Yamasaki, Fumiyuki

× Yamasaki, Fumiyuki

en Yamasaki, Fumiyuki

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Sugiyama, Kazuhiko

× Sugiyama, Kazuhiko

en Sugiyama, Kazuhiko

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Ohtaki, Megu

× Ohtaki, Megu

en Ohtaki, Megu

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Takeshima, Yukio

× Takeshima, Yukio

en Takeshima, Yukio

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Abe, Nobukazu

× Abe, Nobukazu

en Abe, Nobukazu

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Akiyama, Yuuji

× Akiyama, Yuuji

en Akiyama, Yuuji

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Takaba, Junko

× Takaba, Junko

en Takaba, Junko

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Vishwa, Jeet Amatya

× Vishwa, Jeet Amatya

en Vishwa, Jeet Amatya

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Saitou, Taiichi

× Saitou, Taiichi

en Saitou, Taiichi

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Kajiwara, Yoshinori

× Kajiwara, Yoshinori

en Kajiwara, Yoshinori

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Hanaya, Ryosuke

× Hanaya, Ryosuke

en Hanaya, Ryosuke

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Kurisu, Kaoru

× Kurisu, Kaoru

en Kurisu, Kaoru

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2009 Elsevier Ireland Ltd
主題
主題Scheme Other
主題 Apparent diffusion coefficient
主題
主題Scheme Other
主題 Echo planar imaging
主題
主題Scheme Other
主題 Glioblastoma
主題
主題Scheme Other
主題 Magnetic resonance imaging
主題
主題Scheme Other
主題 Overall survival
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Purpose: To retrospectively evaluate whether the mean, minimum, and maximum apparent diffusion coefficient (ADC) of glioblastomas obtained from pretreatment MR images is of prognostic value in patients with glioblastoma. Materials and methods: The institutional review board approved our study and waived the requirement for informed patient consent. Between February 1998 and January 2006, 33 patients (24 males, 9 females; age range 10–76 years) with supratentorial glioblastoma underwent pretreatment magnetic resonance (MR) imaging. The values of the mean, minimum, and maximum ADC (ADCmean, ADCMIN, and ADCMAX, respectively) of each tumor were preoperatively determined from several regions of interest defined in the tumors. After surgical intervention, all patients underwent irradiation and chemotherapy performed according to our hospital protocol. The patient age, symptom duration, Karnofsky performance scale score, extent of surgery, and ADC were assessed using factor analysis of overall survival. Prognostic factors were evaluated using Kaplan–Meier survival curves, the log-rank test, and multiple regression analysis with the Cox proportional hazards model. Results: Likelihood ratio tests confirmed that ADCMIN was the strongest among the three prognostic factors. Total surgical removal was the most important predictive factor for overall survival (P < 0.01). ADCMIN was also statistically correlated with overall survival (P < 0.05) and could be used to classify patients into different prognostic groups. Interestingly, ADCMIN was also the strongest prognostic factor (P < 0.01) in the group of patients in whom total tumor removal was not possible. Conclusion: The ADCMIN value obtained from pretreatment MR images is a useful clinical prognostic biomarker in patients with glioblastoma.
言語 en
出版者
出版者 Elsevier Ireland LTD
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
関連情報
識別子タイプ DOI
関連識別子 10.1016/j.ejrad.2009.01.013
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1016/j.ejrad.2009.01.013
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0720-048X
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA10619405
開始ページ
開始ページ 532
書誌情報 European Journal of Radiology
European Journal of Radiology

巻 73, 号 3, p. 532-537, 発行日 2010-03
旧ID 30408
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