| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components |
|
言語 |
en |
| 作成者 |
Patanasethanont, Denpong
Nagai, Junya
Matsuura, Chie
Fukui, Kyoko
Sutthanut, Khaetthareeya
Sripanidkulchai, Bung-orn
Yumoto, Ryoko
Takano, Mikihisa
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2007 Elsevier B.V. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Multidrug resistance associated-protein |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Kaempferia parviflora |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Flavones |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Multidrug resistance |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
A549 cells |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
In this study, the effects of extracts and flavone derivatives from the rhizome of Kaempferia parviflora on multidrug resistance associated-proteins (MRP)-mediated transport in A549 cells were examined. The cells employed express MRP1 and MRP2, but not P-glycoprotein. The cellular accumulation of calcein, an MRP substrate, was significantly increased by various MRP inhibitors without being affected by verapamil, a typical P-glycoprotein inhibitor. Ethanol and aqueous extracts from Kaempferia parviflora rhizome increased the accumulation of calcein and doxorubicin in A549 cells in a concentration-dependent manner. The inhibitory potency of the ethanol extract for MRP function was greater than that of the aqueous extract. Among six flavone derivatives isolated from Kaempferia parviflora rhizome, 5,7-dimethoxyflavone exhibited a maximal stimulatory effect on the accumulation of doxorubicin in A549 cells. The accumulation of doxorubicin was increased by four flavone derivatives without 5-hydroxy group, but not by the other two flavone derivatives with 5-hydroxy group. In addition, 5,7-dimethoxyflavone and 3,5,7,3',4'-pentamethoxyflavone decreased resistance to doxorubicin in A549 cells. These findings indicate that extracts and flavone derivatives from the rhizome of Kaempferia parviflora suppress MRP function, and therefore may be useful as modulators of multidrug resistance in cancer cells. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Science B.V. |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.ejphar.2007.04.001 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
17481606 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.ejphar.2007.04.001 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0014-2999 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00639687 |
| 開始ページ |
|
|
開始ページ |
67 |
| 書誌情報 |
European Journal of Pharmacology
European Journal of Pharmacology
巻 566,
号 1-3,
p. 67-74,
発行日 2007-07
|
| 旧ID |
20764 |
EJP_566-1-3_67.pdf (178.3 KB)
