| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
The effects of eccentric contraction on myofibrillar proteins in rat skeletal muscle |
|
言語 |
en |
| 作成者 |
Kanzaki, Keita
Kuratani, Mai
Mishima, Takaaki
Matsunaga, Satoshi
Yanaka, Noriyuki
Usui, Sachio
Wada, Masanobu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2010 Springer |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Myosin heavy chain |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Muscle damage |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Stretched contraction |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Proteolysis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Myofibrillar ATPase |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The present study investigated the effects of eccentric muscle contractions (ECC) on the content of myofibrillar proteins (my-proteins) and the catalytic activity of myofibrillar ATPase (my-ATPase) in skeletal muscles. Rat extensor digitorum longus and tibialis anterior muscles were exposed to 200-repeated ECC or isometric contractions (ISC) and used for measures of force output and for biochemical analyses, respectively. Whereas in ISC-treated muscles, full restoration of tetanic force was attained after 2 days of recovery, force developed by ECC-treated muscles remained depressed (P<0.05) after 6 days. The total my-protein content and the relative content of myosin heavy chain (MHC) in total my-proteins were unaltered during 4 days of recovery after ECC, but fell (P<0.05) to 55.9 and 63.4% after 6 days of recovery, respectively. my-ATPase activity expressed on a my-protein weight basis was unaltered immediately after ECC. However, it decreased (P<0.05) to 75.3, 45.3, and 49.3% after 2, 4 and 6 days of recovery, respectively. Total maximal calpain activity measured at 5 mM Ca2+ was significantly augmented (P<0.05) after 2 days of recovery, reaching a level of threefold higher after 6 days. These alterations were specific for ECC and not observed for ISC. These results suggest that depressions in my-ATPase activity contribute to ECC-induced decreases in force and power which can take a number of days to recover. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
関連名称 |
The original publication is available at www.springerlink.com |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00421-010-1579-3 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1007/s00421-010-1579-3 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1439-6319 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11413391 |
| 開始ページ |
|
|
開始ページ |
943 |
| 書誌情報 |
European Journal of Applied Physiology
European Journal of Applied Physiology
巻 110,
号 5,
p. 943-952,
発行日 2010-11
|
| 旧ID |
30874 |
EurJApplPhysiol_110_943.pdf (388.2 KB)
