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Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory

https://hiroshima.repo.nii.ac.jp/records/2006819
https://hiroshima.repo.nii.ac.jp/records/2006819
09033abd-f62e-4040-9d2a-f0e3c4e6b4a4
名前 / ファイル ライセンス アクション
EnvironHealthPrevMed_23_24.pdf EnvironHealthPrevMed_23_24.pdf (664.6 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory
言語 en
作成者 Tsuji, Mayumi

× Tsuji, Mayumi

en Tsuji, Mayumi

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Ishihara, Yasuhiro

× Ishihara, Yasuhiro

en Ishihara, Yasuhiro

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Isse, Toyohi

× Isse, Toyohi

en Isse, Toyohi

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Koriyama, Chihaya

× Koriyama, Chihaya

en Koriyama, Chihaya

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Yamamoto, Megumi

× Yamamoto, Megumi

en Yamamoto, Megumi

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Kakiuchi, Noriaki

× Kakiuchi, Noriaki

en Kakiuchi, Noriaki

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Yu, Hsu-Sheng

× Yu, Hsu-Sheng

en Yu, Hsu-Sheng

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Tanaka, Masayuki

× Tanaka, Masayuki

en Tanaka, Masayuki

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Tsuchiya, Takuto

× Tsuchiya, Takuto

en Tsuchiya, Takuto

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Ohta, Masanori

× Ohta, Masanori

en Ohta, Masanori

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Tanaka, Rie

× Tanaka, Rie

en Tanaka, Rie

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Kawamoto, Toshihiro

× Kawamoto, Toshihiro

en Kawamoto, Toshihiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
主題
主題Scheme Other
主題 Chemical-specific IgG antibodies
主題
主題Scheme Other
主題 Occupational allergy (OA)
主題
主題Scheme Other
主題 Urethane foam factory
主題
主題Scheme Other
主題 Male workers
内容記述
内容記述 Background: Plastic resins are complex chemicals that contain toluene diisocyanate (TDI) and/or trimellitic anhydride (TMA), which cause occupational allergies (OA), including respiratory allergies. Serum IgGs against TDI and TMA have been suggested as potential markers of the exposure status and as exploring cause of OA. Although TDI-specific IgG has been examined for suspected OA, TMA-specific IgG is not commonly evaluated in a urethane foam factory. This study therefore investigated both TDI- and TMA-specific IgGs in suspected OA patients and to evaluate the usefulness of the measurement of multiple chemical-specific IgG measurement for practical monitoring. Methods: Blood samples were collected from two male workers who developed respiratory allergies supposedly caused by occupational exposure to TDI and/or TMA for the presence of TDI- and TMA-specific IgGs. In addition, blood samples from 75 male workers from a urethane foam factory, along with 87 male control subjects, were collected in 2014 and tested for the same IgGs in 2014. The presence and levels of TDI- and TMA-specific serum IgGs were measured using dot blot assays. Results: We found that controls had mean concentrations of TDI- and TMA-specific IgGs of 0.98 and 2.10 μg/mL, respectively. In the two workers with respiratory allergies, the TDI-specific IgG concentrations were 15.6 and 9.51 μg/ mL, and TMA-specific IgG concentrations were 4.56 and 14.4 μg/mL, which are clearly higher than those in controls. Mean concentrations of TDI- and TMA-specific IgGs in the factory workers were 1.89 and 2.41 μg/mL, respectively, and are significantly higher than those of the controls (P < 0.001 and P < 0.026 for TDI- and TMA-specific IgGs, respectively). Conclusion: The workers suspected of OA showed an evidently high level of TDI- and TMA-specific IgG, and these levels in workers at the urethane foam factory were also significantly higher than those in controls. In conclusion, the measurement of TDI- and TMA-specific IgG among workers using plastic resins is helpful to monitor their exposure status.
言語 en
内容記述
内容記述タイプ Other
内容記述 This study was funded by an Industrial Disease Clinical Research Grant (grant number 14040101-02 to M.T.) and the JSPS KAKENHI (grant numbers 22790546 and 25860472 to M.T.).
出版者
出版者 BMC
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1186/s12199-018-0713-4
関連情報
識別子タイプ PMID
関連識別子 29921217
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12199-018-0713-4
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1342-078X
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1347-4715
開始ページ
開始ページ 24
書誌情報 Environmental Health and Preventive Medicine
Environmental Health and Preventive Medicine

巻 23, 号 1, p. 24, 発行日 2018-06-19
旧ID 48689
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