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The Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study

https://hiroshima.repo.nii.ac.jp/records/2006772
https://hiroshima.repo.nii.ac.jp/records/2006772
e5b2d0b2-1756-43e7-a2fc-87620384acdb
名前 / ファイル ライセンス アクション
ebm_2_9_1071.pdf ebm_2_9_1071.pdf (847.0 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル The Japan Statin Treatment Against Recurrent Stroke (J-STARS): A Multicenter, Randomized, Open-label, Parallel-group Study
言語 en
作成者 Hosomi, Naohisa

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en Hosomi, Naohisa

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Nagai, Yoji

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Kohriyama, Tatsuo

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Ohtsuki, Toshiho

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Aoki, Shiro

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Nezu, Tomohisa

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Maruyama, Hirofumi

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en Maruyama, Hirofumi

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Sunami, Norio

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Yokota, Chiaki

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Kitagawa, Kazuo

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Terayama, Yasuo

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Takagi, Makoto

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Ibayashi, Setsuro

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Nakamura, Masakazu

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Origasa, Hideki

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Fukushima, Masanori

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Mori, Etsuro

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Minematsu, Kazuo

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Uchiyama, Shinichiro

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Shinohara, Yukito

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Yamaguchi, Takenori

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Matsumoto, Masayasu

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
主題
主題Scheme Other
主題 Statin
主題
主題Scheme Other
主題 Ischemic stroke
主題
主題Scheme Other
主題 Hemorrhagic stroke
主題
主題Scheme Other
主題 Atherothrombotic infarction
主題
主題Scheme Other
主題 Cholesterol
内容記述
内容記述 Background: Although statin therapy is beneficial for the prevention of initial stroke, the benefit for recurrent stroke and its subtypes remains to be determined in Asian, in whom stroke profiles are different from Caucasian. This study examined whether treatment with low-dose pravastatin prevents stroke recurrence in ischemic stroke patients. Methods: This is a multicenter, randomized, open-label, blinded-endpoint, parallel-group study of patients who experienced non-cardioembolic ischemic stroke. All patients had a total cholesterol level between 4.65 and 6.21 mmol/L at enrollment, without the use of statins. The pravastatin group patients received 10 mg of pravastatin/day; the control group patients received no statins. The primary endpoint was the occurrence of stroke and transient ischemic attack (TIA), with the onset of each stroke subtype set to be one of the secondary endpoints. Finding: Although 3000 patients were targeted, 1578 patients (491 female, age 66.2 years) were recruited and randomly assigned to pravastatin group or control group. During the follow-up of 4.9 ± 1.4 years, although total stroke and TIA similarly occurred in both groups (2.56 vs. 2.65%/year), onset of atherothrombotic infarction was less frequent in pravastatin group (0.21 vs. 0.64%/year, p = 0.0047, adjusted hazard ratio 0.33 [95%CI 0.15 to 0.74]). No significant intergroup difference was found for the onset of other stroke subtypes, and for the occurrence of adverse events. Interpretation: Although whether low-dose pravastatin prevents recurrence of total stroke or TIA still needs to be examined in Asian, this study has generated a hypothesis that it may reduce occurrence of stroke due to larger artery atherosclerosis. Funding: This study was initially supported by a grant from the Ministry of Health, Labour and Welfare, Japan. After the governmental support expired, it was conducted in collaboration between Hiroshima University and the Foundation for Biomedical Research and Innovation.
言語 en
出版者
出版者 Elsevier B.V.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1016/j.ebiom.2015.08.006
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ebiom.2015.08.006
関連情報
識別子タイプ PMID
関連識別子 26501105
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2352-3964
開始ページ
開始ページ 1071
書誌情報 EBioMedicine
EBioMedicine

巻 2, 号 9, p. 1071-1078, 発行日 2015-08
旧ID 48648
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