| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Embryonic dermal condensation and adult dermal papilla induce hair follicles in adult glabrous epidermis through different mechanisms |
|
言語 |
en |
| 作成者 |
Inamatsu, Mutsumi
Tochio, Takumi
Makabe, Aya
Endo, Tetsuya
Oomizu, Souichi
Kobayashi, Eiji
Yoshizato, Katsutoshi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2006 Blackwell Publishing, Inc |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
placode |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
embryonic hairs |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hair germs |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
EGFP-transgenic rats |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hair cycle |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hair follicles |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
recombinant skin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
skin transplantation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
nude mice |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
460 |
| 内容記述 |
|
|
内容記述 |
Hair induction in the adult glabrous epidermis by the embryonic dermis was compared with that by the adult dermis. Recombinant skin, composed of the adult sole epidermis and the embryonic dermis containing dermal condensations (DC), was transplanted onto the back of nude mice. The epidermis of transplants formed hairs. Histology on the induction process demonstrated the formation of placode-like tissues, indicating that the transplant produces hair follicles through a mechanism similar to that underlying hair follicle development in the embryonic skin. An isolated adult rat sole skin piece, inserted with either an aggregate of cultured dermal papilla (DP) cells or an intact DP between its epidermis and dermis, was similarly transplanted. The transplant produced hair follicles. Histology showed that the epidermis in both cases surrounded the aggregates of DP cells. The epidermis never formed placode-like tissues. Thus, it was concluded that the adult epidermal cells recapitulate the embryonic process of hair follicle development when exposed to DC, whereas they get directly into the anagen of the hair cycle when exposed to DP. The expression pattern of Edar and Shh genes, and P-cadherin protein during the hair follicle development in the two types of transplants supported the above conclusion. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Blackwell Publishing |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
16512852 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/j.1440-169X.2006.00848.x |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1111/j.1440-169X.2006.00848.x |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0012-1592 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00627804 |
| 開始ページ |
|
|
開始ページ |
73 |
| 書誌情報 |
Development, Growth and Differentiation
Development, Growth and Differentiation
巻 48,
号 2,
p. 73-86,
発行日 2006-02
|
| 旧ID |
14104 |
DGD_48_2_73-86_2006.pdf (3.8 MB)
