WEKO3
アイテム
Extrachromosomal Double Minutes and Chromosomal Homogeneously Staining Regions as Probes for Chromosome Research
https://hiroshima.repo.nii.ac.jp/records/2006718
https://hiroshima.repo.nii.ac.jp/records/200671882ef8c69-2cf0-4d62-a53b-edeb47711aec
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CGR_124_312.pdf (2.3 MB)
|
| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Extrachromosomal Double Minutes and Chromosomal Homogeneously Staining Regions as Probes for Chromosome Research | |||||||
| 言語 | en | |||||||
| 作成者 |
Shimizu, Noriaki
× Shimizu, Noriaki
|
|||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Double minutes | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Gene amplification | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Homogeneously staining region; Matrix attachment region | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Replication initiation region | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 460 | |||||||
| 内容記述 | ||||||||
| 内容記述 | Gene amplification in human cancer cells generates 2 cytogenetically identifiable structures: extrachromosomal double minutes (DMs) and the chromosomal homogeneously staining region (HSR). DMs are composed of autonomously replicating circular DNA of genomic origin, and they tell us about how the extrachromosomal elements may behave in the cells, how they were entrapped by the micronuclei and how they were eliminated from the cells. On the other hand, the episome model predicts that extrachromosomal elements excised from the chromosome arm might generate DMs, and the breakage-fusion-bridge (BFB) cycle model explains the generation of the HSR. In accordance with this, a plasmid bearing a mammalian replication initiation region (IR) and a matrix attachment region (MAR) mimics gene amplification and generates DMs and HSRs de novo. The IR/MAR gene amplification system extends our understanding of the mechanism of gene amplification and the behavior of amplified genes. Furthermore, the system may suggest the way how extrachromosomal elements in general may alter the chromosome architecture and function. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Karger | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AO | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1159/000218135 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | http://dx.doi.org/10.1159/000218135 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1424-8581 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA11703143 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 312 | |||||||
| 書誌情報 |
Cytogenetic and Genome Research Cytogenetic and Genome Research 巻 124, 号 3-4, p. 312-326, 発行日 2009 |
|||||||
| 旧ID | 27768 | |||||||
