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Klotho as a Therapeutic Target during the Development of Renal Fibrosis
https://hiroshima.repo.nii.ac.jp/records/2006709
https://hiroshima.repo.nii.ac.jp/records/20067098ce1bd09-106c-429f-80ca-b04e0b5d1aa4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ContribNephrol_189_178.pdf (380.6 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Klotho as a Therapeutic Target during the Development of Renal Fibrosis | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Doi, Shigehiro
× Doi, Shigehiro
× Masaki, Takao
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | © 2017 S. Karger AG, Basel. | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | This is the peer-reviewed but unedited manuscript version of the following article: Contrib Nephrol. 2017;189:178-183. (DOI: 10.1159/000450776). The final, published version is available at http://www.karger.com/?doi=10.1159/000450776 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Aging | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Klotho | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Renal fibrosis | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | TGF-β1 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Histone methylation | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Systemic symptoms such as the ectopic calcification, atrophy of skin and muscle, and impaired sexual function observed in chronic kidney diseases (CKD) have been reported to coincide with those observed in geriatric symptoms. Regarding the kidney, clinical/pathological characteristics in CKD patients also coincide with those in the aging kidney. These findings suggest common mechanisms in the development of both CKD and aging. Our investigation of aging factors associated with renal fibrosis in IgA nephropathy patients revealed a significant correlation between accumulation of cells with an arrested cell cycle and decreased expression of Klotho protein. Because cell cycle arrest has a protective effect on organs in the acute phase, the proposed therapeutic target against the aging process is to maintain expression of Klotho protein. In addition, it is recognized that TGF-β1 plays a central role in the development of renal fibrosis. However, TGF-β1 has also been reported to decrease expression of Klotho protein. In this report, we provide an interpretation of our new treatment strategy which involves controlling histone methylation. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Scientific Aspects of Dialysis Therapy: JSDT/ISBP Anniversary Edition. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | This work was supported by the Grant-in-Aid for Scientific Research (KAKENHI) No.16K09610 (to S.D.) in Hiroshima University. | |||||||||
| 出版者 | ||||||||||
| 出版者 | S. Karger AG, Basel. | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AO | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1159/000450776 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 27951565 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1159/000450776 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0302-5144 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1662-2782 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 178 | |||||||||
| 書誌情報 |
Contributions to Nephrology Contributions to Nephrology 巻 189, p. 178-183, 発行日 2016-12-12 |
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| 旧ID | 47590 | |||||||||
