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Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major
https://hiroshima.repo.nii.ac.jp/records/2006685
https://hiroshima.repo.nii.ac.jp/records/200668562201c99-90dd-4092-b9fb-2e99b8d73d44
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CPB_151_268.pdf (1.7 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Molecular characterization of peroxisome proliferator-activated receptors (PPARs) and their gene expression in the differentiating adipocytes of red sea bream Pagrus major | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Oku, Hiromi
× Oku, Hiromi
× Umino, Tetsuya
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | Copyright (c) 2008 Elsevier Inc | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | adipocyte | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cloning | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | differentiation | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | in vitro | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | fish | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | gene | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | PPAR | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | red sea bream | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 660 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | To investigate the molecular mechanism of fish adipocyte differentiation, the three subtypes of PPAR genes (α, β and γ) were characterized in a marine teleost red sea bream (Pagrus major). The primary structures of red sea bream PPARs exhibited high degrees of similarities to their mammalian counterparts, and their gene expression was detected in various tissues including adipose tissue, heart and hepatopancreas. During the differentiation of primary cultured red sea bream adipocytes, three PPARs showed distinct expression patterns: The α subtype showed a transient increase and the β gene expression tended to increase during adipocyte differentiation whereas the gene expression level of PPARγ did not change. These results suggest that they play distinct roles in adipocyte differentiation in red sea bream. In the differentiating red sea bream adipocytes, mammalian PPAR agonists, 15-deoxy-∆12,14-prostaglandin J2, ciglitazone and fenofibrate did not show clear effects on the adipogenic gene expression. However, 2-bromopalmitate increased the PPARγ and related adipogenic gene expression levels, suggesting the γ subtype plays a central role in red sea bream adipocyte differentiation and in addition, fatty acid metabolites can be used as modulators of adipocyte function. Thus our study highlighted the roles of PPARs in fish adipocyte differentiation and provided information on the molecular mechanisms of fish adipocyte development. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Elsevier Inc | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AO | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1016/j.cbpb.2008.07.007 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 18691667 | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.1016/j.cbpb.2008.07.007 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA11045017 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1096-4959 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 268 | |||||||||
| 書誌情報 |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 巻 151, 号 3, p. 268-277, 発行日 2008-11 |
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| 旧ID | 25583 | |||||||||
