| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice |
|
言語 |
en |
| 作成者 |
Sakayori, Nobuyuki
Katakura, Masanori
Hamazaki, Kei
Higuchi, Oki
Fujii, Kazuki
Fukabori, Ryoji
Iguchi, Yoshio
Setogawa, Susumu
Takao, Keizo
Miyazawa, Teruo
Arita, Makoto
Kobayashi, Kazuto
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. |
| 内容記述 |
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内容記述 |
The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and low in omega-3 (n-3) PUFAs (an n-6high/n-3low diet), whose n-6/n-3 ratio is approximately 120, induces hedonic consumption in the offspring by upregulating the midbrain dopaminergic system. We found that exposure to the n-6high/n-3low diet specifically increases the consumption of palatable foods via increased mesolimbic dopamine release. In addition, neurodevelopmental analyses revealed that this induced hedonic consumption is programmed during embryogenesis, as dopaminergic neurogenesis is increased during in utero access to the n-6high/n-3low diet. Our findings reveal that maternal consumption of PUFAs can have long-lasting effects on the offspring’s pattern for consuming highly palatable foods. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by JSPS KAKENHI Grant Numbers JP16H06276, JP17H06059, JP17J10395, JP19H05023, and JP19K20184 (to N.S.), the Grant for Young Scientists from the Japan Society of Nutrition and Food Science (to N.S.), and the Otsuka Award from the Japan Society for Lipid Nutrition (to N.S.). |
| 出版者 |
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|
出版者 |
Nature Research |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/s42003-020-01209-4 |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s42003-020-01209-4 |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2399-3642 |
| 開始ページ |
|
|
開始ページ |
473 |
| 書誌情報 |
Communications Biology
Communications Biology
巻 3,
p. 473,
発行日 2020-08-28
|
| 旧ID |
51526 |
CommBiol_3_473.pdf (2.7 MB)
