| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice |
|
言語 |
en |
| 作成者 |
Minamizaki, Tomoko
Nakao, Yuko
Irie, Yasumasa
Ahmed, Faisal
Itoh, Shota
Sarmin, Nushrat
Yoshioka, Hirotaka
Nobukiyo, Asako
Fujimoto, Chise
Niida, Shumpei
Sotomaru, Yusuke
Tanimoto, Kotaro
Kozai, Katsuyuki
Sugiyama, Toshie
Bonnelye, Edith
Takei, Yuichiro
Yoshiko, Yuji
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| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. |
| 内容記述 |
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内容記述 |
Communication between osteoblasts and osteoclasts plays a key role in bone metabolism. We describe here an unexpected role for matrix vesicles (MVs), which bud from boneforming osteoblasts and have a well-established role in initiation of bone mineralization, in osteoclastogenesis. We show that the MV cargo miR-125b accumulates in the bone matrix, with increased accumulation in transgenic (Tg) mice overexpressing miR-125b in osteoblasts. Bone formation and osteoblasts in Tg mice are normal, but the number of bone-resorbing osteoclasts is reduced, leading to higher trabecular bone mass. miR-125b in the bone matrix targets and degrades Prdm1, a transcriptional repressor of anti-osteoclastogenic factors, in osteoclast precursors. Overexpressing miR-125b in osteoblasts abrogates bone loss in different mouse models. Our results show that the MV cargo miR-125b is a regulatory element of osteoblast-osteoclast communication, and that bone matrix provides extracellular storage of miR-125b that is functionally active in bone resorption. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
T.M. and Y.T. were supported in part by MEXT KAKENHI (JP16K11443, T.M.; JP26861548, Y.T.). Y.Y. was supported by MEXT KAKENHI (JP18K19647), the Raffinee International Foundation and the Ono Pharmaceutical Foundation. |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
Supplementary information is available for this paper at https://doi.org/10.1038/s42003-020-0754-2. |
| 出版者 |
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出版者 |
Nature Research |
| 言語 |
|
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言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1038/s42003-020-0754-2 |
| 関連情報 |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
31949279 |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s42003-020-0754-2 |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2399-3642 |
| 開始ページ |
|
|
開始ページ |
30 |
| 書誌情報 |
Communications Biology
Communications Biology
巻 3,
p. 30,
発行日 2020-01-16
|
| 旧ID |
48981 |
CommunBiol_3_30.pdf (2.3 MB)
