| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids |
|
言語 |
en |
| 作成者 |
Baba, Takashi
Otake, Hiroyuki
Inoue, Miki
Sato, Tetsuya
Ishihara, Yasuhiro
Moon, Ju-Yeon
Tsuchiya, Megumi
Miyabayashi, Kanako
Ogawa, Hidesato
Shima, Yuichi
Wang, Lixiang
Sato, Ryuichiro
Yamazaki, Takeshi
Suyama, Mikita
Nomura, Masatoshi
Choi, Man Ho
Ohkawa, Yasuyuki
Morohashi, Ken-ichirou
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. |
| 内容記述 |
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内容記述 |
Housekeeping metabolic pathways such as glycolysis are active in all cell types. In addition, many types of cells are equipped with cell-specific metabolic pathways. To properly perform their functions, housekeeping and cell-specific metabolic pathways must function cooperatively. However, the regulatory mechanisms that couple metabolic pathways remain largely unknown. Recently, we showed that the steroidogenic cell-specific nuclear receptor Ad4BP/ SF-1, which regulates steroidogenic genes, also regulates housekeeping glycolytic genes. Here, we identify cholesterogenic genes as the targets of Ad4BP/SF-1. Further, we reveal that Ad4BP/SF-1 regulates Hummr, a candidate mediator of cholesterol transport from endoplasmic reticula to mitochondria. Given that cholesterol is the starting material for steroidogenesis and is synthesized from acetyl-CoA, which partly originates from glucose, our results suggest that multiple biological processes involved in synthesizing steroid hormones are governed by Ad4BP/SF-1. To our knowledge, this study provides the first example where housekeeping and cell-specific metabolism are coordinated at the transcriptional level. |
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言語 |
en |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
This work was supported by Grants 16H05142 (K.M.), 17H06427 (K.M.), 16K08593 (T.B.), and 17J03270 (M.I.) from the Japan Society for the Promotion of Science (JSPS) KAKENHI; The Uehara Memorial Foundation (K.M.); Takeda Science Foundation (T.B.); The Shin-Nihon of Advanced Medical Research (T.B.). |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
Supplementary information accompanies this paper at https://doi.org/10.1038/s42003-018-0020-z. |
| 出版者 |
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出版者 |
Nature Research |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1038/s42003-018-0020-z |
| 関連情報 |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
30271905 |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s42003-018-0020-z |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2399-3642 |
| 開始ページ |
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|
開始ページ |
18 |
| 書誌情報 |
Communications Biology
Communications Biology
巻 1,
p. 18,
発行日 2018-03-22
|
| 旧ID |
48687 |
CommunBiol_1_18.pdf (836.0 KB)
