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Complete response to pembrolizumab in advanced hepatocellular carcinoma with microsatellite instability

https://hiroshima.repo.nii.ac.jp/records/2006663
https://hiroshima.repo.nii.ac.jp/records/2006663
3283f55c-5d2a-4d94-aaff-1e86c8362669
名前 / ファイル ライセンス アクション
ClinJGastroenterol_13_867.pdf ClinJGastroenterol_13_867.pdf (1.4 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Complete response to pembrolizumab in advanced hepatocellular carcinoma with microsatellite instability
言語 en
作成者 Ando, Yuwa

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en Ando, Yuwa

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Yamauchi, Masami

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en Yamauchi, Masami

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Suehiro, Yosuke

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Yamaoka, Kenji

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Kosaka, Yumi

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Fuji, Yasutomo

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Uchikawa, Shinsuke

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Kodama, Kenichiro

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Morio, Kei

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Fujino, Hatsue

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Nakahara, Takashi

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Ono, Atsushi

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Murakami, Eisuke

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Kawaoka, Tomokazu

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Takahashi, Shoichi

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Tsuge, Masataka

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Hiramatsu, Akira

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Imamura, Michio

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Chayama, Kazuaki

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Aikata, Hiroshi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 This is a post-peer-review, pre-copyedit version of an article published in Clinical Journal of Gastroenterology. The final authenticated version is available online at: https://doi.org/10.1007/s12328-020-01099-3
権利情報
権利情報 This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
主題
主題Scheme Other
主題 Hepatocellular carcinoma
主題
主題Scheme Other
主題 Mismatch repair deficiency
主題
主題Scheme Other
主題 MSI-high
主題
主題Scheme Other
主題 Immune checkpoint blockade
主題
主題Scheme Other
主題 PD-L1
内容記述
内容記述 Hepatocellular carcinoma (HCC) has limited systemic treatment options and a poor prognosis. The immune checkpoint inhibitor pembrolizumab was recently approved for the treatment of solid tumors with microsatellite instability (MSI). However, its clinical utility for the management of HCC remains to be clarified. Here, we present a case of unresectable HCC with MSI that showed an impressive response to pembrolizumab treatment. A 64-year-old man with chronic HCV infection was diagnosed with a large HCC. His severe liver dysfunction and poor performance status prevented any treatment option other than sorafenib. However, sorafenib failed after a few days due to the rapid progression of the tumor. Based on the finding of MSI in a biopsy specimen, immunotherapy using pembrolizumab was initiated. A dramatic improvement in his general condition and a reduction in tumor size were observed after the initiation of pembrolizumab treatment. Among a cohort of 50 consecutive patients with advanced HCC who were refractory to standard systemic therapy, MSI was found only in the present case. Immune checkpoint blockade therapy induced prominent anti-tumor effects in HCC with MSI. Screening for defects in DNA mismatch repair function may be warranted in HCC patients despite the low frequency of MSI.
言語 en
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
関連情報
識別子タイプ DOI
関連識別子 10.1007/s12328-020-01099-3
関連情報
識別子タイプ PMID
関連識別子 32020539
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s12328-020-01099-3
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1865-7257
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1865-7265
開始ページ
開始ページ 867
書誌情報 Clinical Journal of Gastroenterology
Clinical Journal of Gastroenterology

巻 13, 号 5, p. 867-872, 発行日 2020-10
旧ID 50461
備考 Post-print version/PDF may be used in an institutional repository after an embargo period of 12 months.
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