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Circulating visfatin level is correlated with inflammation, but not with insulin resistance

https://hiroshima.repo.nii.ac.jp/records/2006662
https://hiroshima.repo.nii.ac.jp/records/2006662
c40ba9ae-ae92-4c08-b58f-d1567b135dec
名前 / ファイル ライセンス アクション
CliEndocrinol_67_796.pdf CliEndocrinol_67_796.pdf (198.8 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Circulating visfatin level is correlated with inflammation, but not with insulin resistance
言語 en
作成者 Oki, Kenji

× Oki, Kenji

en Oki, Kenji

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Yamane, Kiminori

× Yamane, Kiminori

en Yamane, Kiminori

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Kamei, Nozomu

× Kamei, Nozomu

en Kamei, Nozomu

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Nojima, Hideki

× Nojima, Hideki

en Nojima, Hideki

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Kohno, Nobuoki

× Kohno, Nobuoki

en Kohno, Nobuoki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright(c) 2007 Blackwell Publishing
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Objective Recent studies, both in vitro and in vivo, have indicated that visfatin is one of the inflammatory cytokines, although the relationship between visfatin and insulin resistance remains inconclusive. Accordingly, we assessed the association between visfatin concentrations in serum and those of interleukin-6 (IL-6) and C-reactive protein (CRP), known as markers of systemic inflammation, and also investigated the relationship between these serum concentrations and insulin resistance. Design and method A total of 295 Japanese Americans living in Hawaii (126 men and 169 women, mean age 68.7 +/- 14.9 years) were enrolled. The serum levels of visfatin, IL-6 and CRP levels were measured, and homeostasis model assessment for insulin resistance (HOMA-IR) was calculated as a marker of insulin resistance. Results Significant positive correlations were found between serum levels of visfatin and IL-6 or CRP (r=0.271, P < 0.001; r = 0.118, P < 0.05, respectively). Multiple regression analysis revealed that correlations between serum levels of visfatin and IL-6 or CRP remained significant after adjustments for age, sex, body mass index, per cent body fat and waist girth. There was no significant trend of the HOMA-IR for the tertiles of serum concentrations of visfatin. On the other hand, a significant trend towards increase of HOMA-IR with increasing tertile of serum concentrations, from the lowest to the highest, was observed for both IL-6 and CRP. The HOMA-IR in subjects with serum concentration of IL-6 or CRP in the highest or intermediate tertiles of IL-6 or CRP were significantly higher than that in subjects in the lowest tertile, even after adjustment for age and sex (IL-6: P < 0.001 and P < 0.001, respectively; CRP: P < 0.001 and P < 0.01, respectively). Conclusion Serum visfatin levels were positively correlated with the serum levels of IL-6 and slightly related with serum levels of CRP, but not with HOMA-IR, in Japanese Americans. Our results indicate that circulating visfatin may reflect inflammation status.
言語 en
出版者
出版者 Blackwell Publishing
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
関連情報
関連名称 The definite version is avairable at www.blackwell-synergy.com
関連情報
識別子タイプ DOI
関連識別子 10.1111/j.1365-2265.2007.02966.x
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1111/j.1365-2265.2007.02966.x
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0300-0664
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00607669
開始ページ
開始ページ 796
書誌情報 Clinical Endocrinology
Clinical Endocrinology

巻 67, 号 5, p. 796-800, 発行日 2007-11
旧ID 21468
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