| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Association Between Plasma High-Molecular-Weight Adiponectin and Coronary Plaque Characteristics Assessed by Computed Tomography Angiography in Conditions of Visceral Adipose Accumulation |
|
言語 |
en |
| 作成者 |
Kunita, Eiji
Yamamoto, Hideya
Kitagawa, Toshiro
Ohashi, Norihiko
Utsunomiya, Hiroto
Oka, Toshiharu
Horiguchi, Jun
Awai, Kazuo
Kihara, Yasuki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2012 The Japanese Circulation Society. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Adiponectin |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Computed tomography |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Plaque |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Background: Our group has previously reported that visceral adipose tissue (VAT) accumulation was associated with the extent and vulnerable characteristics of coronary plaques using coronary computed tomography angiography (CTA). An investigation of the associations between these coronary lesions with plasma adiponectin and leptin was performed. Methods and Results: A total of 394 patients (220 men and 174 women) in the study were referred for CTA. Plain abdominal scanning was simultaneously performed to evaluate VAT areas. The median level of plasma high-molecular-weight (HMW) adiponectin in patients with CTA-based obstructive coronary artery disease was significantly lower than that in patients without (men: 1.45 vs. 1.88μg/ml, P=0.002; women: 2.49 vs. 3.44μg/ml, P<0.001). Multivariate analyses revealed that a lower HMW adiponectin concentration was significantly associated with the presence (men: P=0.019; women: P=0.018) and involved segment numbers (men: P=0.001; women: P=0.003) of coronary plaques. Furthermore, it was significantly related to coronary plaque with all 3 vulnerable characteristics of positive remodeling, low CT density (≤38 Hounsfield units), and adjacent spotty calcium (men: P=0.019; women: P=0.016). These associations were also observed with VAT areas, but not with plasma leptin concentrations, in both genders. Conclusions: Lower plasma HMW adiponectin is associated with the presence, extent, and vulnerable characteristics of coronary plaques assessed by CTA in both genders. (Circ J 2012; 76: 1687–1696) |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
一般社団法人日本循環器学会 |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1253/circj.CJ-11-1442 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1253/circj.CJ-11-1442 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1346-9843 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11591968 |
| 開始ページ |
|
|
開始ページ |
1687 |
| 書誌情報 |
Circulation Journal
Circulation Journal
巻 76,
号 7,
p. 1687-1696,
発行日 2012
|
| 旧ID |
34079 |
76_CJ-11-1442.pdf (3.2 MB)
