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A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth

https://hiroshima.repo.nii.ac.jp/records/2006558
https://hiroshima.repo.nii.ac.jp/records/2006558
99480986-3e7e-4d16-bac6-b5f2111490d7
名前 / ファイル ライセンス アクション
Cancers_11_589.pdf Cancers_11_589.pdf (3.1 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth
言語 en
作成者 Vogel, Christoph F. A.

× Vogel, Christoph F. A.

en Vogel, Christoph F. A.

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Ishihara, Yasuhiro

× Ishihara, Yasuhiro

en Ishihara, Yasuhiro

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Campbell, Claire E.

× Campbell, Claire E.

en Campbell, Claire E.

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Kado, Sarah Y.

× Kado, Sarah Y.

en Kado, Sarah Y.

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Nguyen-Chi, Aimy

× Nguyen-Chi, Aimy

en Nguyen-Chi, Aimy

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Sweeney, Colleen

× Sweeney, Colleen

en Sweeney, Colleen

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Pollet, Marius

× Pollet, Marius

en Pollet, Marius

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Haarmann-Stemmann, Thomas

× Haarmann-Stemmann, Thomas

en Haarmann-Stemmann, Thomas

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Tuscano, Joseph M.

× Tuscano, Joseph M.

en Tuscano, Joseph M.

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
主題
主題Scheme Other
主題 AhR
主題
主題Scheme Other
主題 AhRR
主題
主題Scheme Other
主題 carcinogenicity
主題
主題Scheme Other
主題 C/EBPβ
主題
主題Scheme Other
主題 cyclooxygenase 2
主題
主題Scheme Other
主題 inflammation
主題
主題Scheme Other
主題 interleukin 1
主題
主題Scheme Other
主題 lymphoma
主題
主題Scheme Other
主題 TCDD
内容記述
内容記述 The aryl hydrocarbon receptor (AhR) is known for mediating the toxicity of environmental pollutants such as dioxins and numerous dioxin-like compounds, and is associated with the promotion of various malignancies, including lymphoma. The aryl hydrocarbon receptor repressor (AhRR), a ligand-independent, transcriptionally inactive AhR-like protein is known to repress AhR signaling through its ability to compete with the AhR for dimerization with the AhR nuclear translocator (ARNT). While AhRR effectively blocks AhR signaling, several aspects of the mechanism of AhRR’s functions are poorly understood, including suppression of inflammatory responses and its putative role as a tumor suppressor. In a transgenic mouse that overexpresses AhRR (AhRR Tg) we discovered that these mice suppress 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)- and inflammation-induced tumor growth after subcutaneous challenge of EL4 lymphoma cells. Using mouse embryonic fibroblasts (MEF) we found that AhRR overexpression suppresses the AhR-mediated anti-apoptotic response. The AhRR-mediated inhibition of apoptotic resistance was associated with a suppressed expression of interleukin (IL)-1β and cyclooxygenase (COX)-2, which was dependent on activation of protein kinase A (PKA) and the CAAT-enhancer-binding protein beta (C/EBPβ). These results provide mechanistic insights into the role of the AhRR to suppress inflammation and highlight the AhRR as a potential therapeutic target to suppress tumor growth.
言語 en
内容記述
内容記述タイプ Other
内容記述 Research reported in this publication is supported in part by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number R01 ES029126 and R21 ES030419, the core center grant, P30-ES023513 from the National Institute of Environmental Health Sciences, and by the University of California Davis Cancer Center support grant P30 CA093373 and the Cancer Immunology Grant fund 48649. Its contents are solely the responsibility of the authors and do not necessarily represent the offcial views of the National Institutes of Health.
出版者
出版者 MDPI
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.3390/cancers11050589
関連情報
識別子タイプ PMID
関連識別子 31035533
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/cancers11050589
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2072-6694
開始ページ
開始ページ 589
書誌情報 Cancers
Cancers

巻 11, 号 5, p. 589, 発行日 2019-04-27
旧ID 48682
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