| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth |
|
言語 |
en |
| 作成者 |
Vogel, Christoph F. A.
Ishihara, Yasuhiro
Campbell, Claire E.
Kado, Sarah Y.
Nguyen-Chi, Aimy
Sweeney, Colleen
Pollet, Marius
Haarmann-Stemmann, Thomas
Tuscano, Joseph M.
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
AhR |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
AhRR |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
carcinogenicity |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
C/EBPβ |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cyclooxygenase 2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
inflammation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
interleukin 1 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
lymphoma |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
TCDD |
| 内容記述 |
|
|
内容記述 |
The aryl hydrocarbon receptor (AhR) is known for mediating the toxicity of environmental pollutants such as dioxins and numerous dioxin-like compounds, and is associated with the promotion of various malignancies, including lymphoma. The aryl hydrocarbon receptor repressor (AhRR), a ligand-independent, transcriptionally inactive AhR-like protein is known to repress AhR signaling through its ability to compete with the AhR for dimerization with the AhR nuclear translocator (ARNT). While AhRR effectively blocks AhR signaling, several aspects of the mechanism of AhRR’s functions are poorly understood, including suppression of inflammatory responses and its putative role as a tumor suppressor. In a transgenic mouse that overexpresses AhRR (AhRR Tg) we discovered that these mice suppress 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)- and inflammation-induced tumor growth after subcutaneous challenge of EL4 lymphoma cells. Using mouse embryonic fibroblasts (MEF) we found that AhRR overexpression suppresses the AhR-mediated anti-apoptotic response. The AhRR-mediated inhibition of apoptotic resistance was associated with a suppressed expression of interleukin (IL)-1β and cyclooxygenase (COX)-2, which was dependent on activation of protein kinase A (PKA) and the CAAT-enhancer-binding protein beta (C/EBPβ). These results provide mechanistic insights into the role of the AhRR to suppress inflammation and highlight the AhRR as a potential therapeutic target to suppress tumor growth. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Research reported in this publication is supported in part by the National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number R01 ES029126 and R21 ES030419, the core center grant, P30-ES023513 from the National Institute of Environmental Health Sciences, and by the University of California Davis Cancer Center support grant P30 CA093373 and the Cancer Immunology Grant fund 48649. Its contents are solely the responsibility of the authors and do not necessarily represent the offcial views of the National Institutes of Health. |
| 出版者 |
|
|
出版者 |
MDPI |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3390/cancers11050589 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
31035533 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/cancers11050589 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2072-6694 |
| 開始ページ |
|
|
開始ページ |
589 |
| 書誌情報 |
Cancers
Cancers
巻 11,
号 5,
p. 589,
発行日 2019-04-27
|
| 旧ID |
48682 |
Cancers_11_589.pdf (3.1 MB)
