| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases |
|
言語 |
en |
| 作成者 |
Ishida, Atsuhiko
Sueyoshi, Noriyuki
Shigeri, Yasushi
Kameshita, Isamu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright (c) 2008 Nature Publishing Group |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
Ca2+/calmodulin-dependent protein kinase |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
protein phosphatase |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
phosphorylation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
dephosphorylation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
deactivation |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
disease |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
pathogenesis |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
inhibitor |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
chemical screening |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
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|
内容記述 |
Multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) play pivotal roles in intracellular Ca2+ signaling pathways. There is growing evidence that CaMKs are involved in the pathogenic mechanisms underlying various human diseases. In this review, we begin by briefly summarizing our knowledge of the involvement of CaMKs in the pathogenesis of various diseases suggested to be caused by the dysfunction/dysregulation or aberrant expression of CaMKs. It is widely known that the activities of CaMKs are strictly regulated by protein phosphorylation /dephosphorylation of specific phosphorylation sites. Since phosphorylation status is balanced by protein kinases and protein phosphatases, the mechanism of dephosphorylation/deactivation of CaMKs, corresponding to their “switching off", is extremely important, as is the mechanism of phosphorylation/activation corresponding to their “switching on". Therefore, we focus on the regulation of multifunctional CaMKs by protein phosphatases. We summarize the current understanding of negative regulation of CaMKs by protein phosphatases. We also discuss the biochemical properties and physiological significance of a protein phosphatase that we designated as Ca2+ /calmodulin-dependent protein kinase phosphatase (CaMKP), and those of its homologue CaMKP-N. Pharmacological applications of CaMKP inhibitors are also discussed. These compounds may be useful not only for exploring the physiological functions of CaMKP/CaMKP-N, but also as novel chemotherapies for various diseases. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nature Publishing Group |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1038/bjp.2008.127 |
| 関連情報 |
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|
識別子タイプ |
PMID |
|
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関連識別子 |
18454172 |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1038/bjp.2008.127 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0007-1188 |
| 収録物識別子 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00574810 |
| 開始ページ |
|
|
開始ページ |
729 |
| 書誌情報 |
British Journal of Pharmacology
British Journal of Pharmacology
巻 154,
号 4,
p. 729-740,
発行日 2008-05
|
| 旧ID |
25577 |
BJP_154_729_.pdf (426.4 KB)
